Are transepidermal water loss and clinical signs correlated in canine atopic dermatitis? A compilation of studies

Veterinary Dermatology
Rosanna Marsella

Abstract

Cutaneous impairment plays a crucial role in atopic dermatitis (AD). Transepidermal water loss (TEWL) measurement is an indirect assessment of skin barrier function and correlates with disease severity in humans. Skin impairment also exists in canine AD; however, concerns exist regarding variability and reliability of TEWL measurements in dogs. The purposes of this retrospective study were twofold: first, to investigate the correlation between severity of dermatitis [measured by Canine Atopic Dermatitis Extent and Severity Index (CADESI)] and TEWL; and second, to evaluate whether increased TEWL at a young age correlates with disease severity later in life. Data from atopic beagles and dogs with natural AD were analysed. Transepidermal water loss was measured in atopic beagles (n=24) with an open chamber and in dogs with naturally occurring AD with a closed chamber device (two studies, with n=14 and n=18). Pearson product-moment correlation was used for analyses. Transepidermal water loss of the inguinal region, axilla, antebrachial flexure and pinna was analysed. Correlations were investigated for each study, separately first and then jointly. They included CADESI and TEWL of individual regions, total CADESI and total TEWL of a...Continue Reading

References

Jan 5, 1999·Clinical and Diagnostic Laboratory Immunology·Y OhnishiS Imayama
Feb 13, 2007·The Journal of Allergy and Clinical Immunology·Toshifumi NomuraHiroshi Shimizu
Nov 9, 2007·Acta Dermato-venereologica·Thomas HubicheFranck Boralevi
Feb 6, 2008·The Journal of Allergy and Clinical Immunology·Jayanta GuptaGurjit K Khurana Hershey
Feb 27, 2008·Critical Reviews in Immunology·Sarita SehraMark H Kaplan
Sep 6, 2008·The Journal of Veterinary Medical Science·Kenichiro ShimadaToshiroh Iwasaki
Sep 27, 2008·The Journal of Investigative Dermatology·Ikue Nemoto-HasebeHiroshi Shimizu
Jun 6, 2009·The Journal of Investigative Dermatology·Michael J CorkSimon J Ward
Jun 12, 2009·The Journal of Investigative Dermatology·Rosanna Marsella, Giampiero Girolomoni
Jun 25, 2009·Current Opinion in Allergy and Clinical Immunology·Peter M Elias, Matthias Schmuth
Aug 7, 2009·Current Allergy and Asthma Reports·Peter M Elias, Matthias Schmuth
Feb 25, 2010·Veterinary Dermatology·Rosanna MarsellaLisa Harrington
Dec 22, 2010·Allergology International : Official Journal of the Japanese Society of Allergology·Rinko OsawaHiroshi Shimizu
Mar 19, 2011·Veterinary Dermatology·Rosanna MarsellaUNKNOWN International Task Force on Canine Atopic Dermatitis
Jun 9, 2011·Experimental Dermatology·Ji-Seon YoonToshiroh Iwasaki

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Citations

Jan 22, 2013·Veterinary Dermatology·Rosanna Marsella
Feb 17, 2015·Veterinary Dermatology·Domenico SantoroPetra Bizikova
Jan 17, 2017·Polish Journal of Veterinary Sciences·M P SzczepanikZ J H Pomorski
Apr 24, 2021·Veterinary Dermatology·Rosanna Marsella

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.