Are users of lipid-lowering drugs at increased risk of peripheral neuropathy?

European Journal of Clinical Pharmacology
D GaistS H Sindrup

Abstract

To estimate the risk of peripheral neuropathy associated with use of lipid-lowering drugs. Population-based dynamic cohort study based on data from general practices in the United Kingdom from 1991 to 1997. Three cohorts of individuals aged 40-74 years were identified: a cohort of 17,219 persons who received at least one prescription for lipid-lowering drugs in the period; a second cohort of patients with a hyperlipidaemia diagnosis who had not been prescribed lipid-lowering drugs (n = 28,974) and a third cohort comprised of 50,000 individuals from the general population. The incidence rates of peripheral neuropathy in the three cohorts were calculated and the relative risk of peripheral neuropathy in users of lipid-lowering drugs was compared with non-users from the general population cohort. The incidence rate of idiopathic peripheral neuropathy in users of lipid-lowering drugs was higher [0.73 per 10,000 person-years, 95% confidence interval (CI) 0.01-2.62] than in the hyperlipidaemia non-treated cohort (0.40 per 10,000 person-years, CI 0.05-1.46) and the general population cohort (0.46 per 10,000 person-years, CI 0.13-1.18). The raised risk of idiopathic peripheral neuropathy in users of lipid-lowering drugs was confined to...Continue Reading

Citations

Jan 23, 2002·Pharmacoepidemiology and Drug Safety
Feb 4, 2006·Current Atherosclerosis Reports·Anup K Sabharwal, Jeffrey B Boord
Apr 23, 2004·Current Neurology and Neuroscience Reports·Olaf StüveScott S Zamvil
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Martin S WeberScott S Zamvil
Mar 1, 2005·Parkinsonism & Related Disorders·Abraham LiebermanRobert Myerburg
Mar 18, 2003·Journal of the Neurological Sciences·Y L LoC E Tan
Aug 26, 2006·Nature Clinical Practice. Neurology·Martin S WeberScott S Zamvil
Aug 10, 2010·Brain : a Journal of Neurology·Marieke BiegstraatenIvo N van Schaik
Nov 18, 2004·Journal of Epidemiology and Community Health·Giovanni CorraoPaolo Contiero
Mar 25, 2005·Journal of Negative Results in Biomedicine·Nusrat ShafiqAnil Grover
Jan 23, 2009·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Beatrice A Golomb, Marcella A Evans
Mar 18, 2008·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Pavel OtrubaPetr Hlustik
Aug 3, 2014·The Journal of Pain : Official Journal of the American Pain Society·Shrutya BhallaAmteshwar Singh Jaggi
Feb 5, 2008·La Presse médicale·Geneviève DurrieuUNKNOWN Réseau français des centres régionaux de pharmacovigilance (CRPVs)
Nov 11, 2006·Atherosclerosis·D N KiortsisE N Liberopoulos
Oct 6, 2004·Pharmacotherapy·Pang H ChongRussell E Bartt
May 16, 2014·CPT: Pharmacometrics & Systems Pharmacology·J HurJ P F Bai
Jul 25, 2006·Journal of Neuroimmunology·Martin S WeberScott S Zamvil
Apr 4, 2006·The American Journal of Cardiology·Malcolm Law, Alicja R Rudnicka
Apr 4, 2006·The American Journal of Cardiology·Lawrence M BrassUNKNOWN National Lipid Association Statin Safety Task Force Neurology Expert Panel
Apr 4, 2006·The American Journal of Cardiology·Harold Bays
Apr 22, 2005·The American Journal of Cardiology·Jeffrey L AndersonBenjamin D Horne
Sep 23, 2003·Expert Opinion on Therapeutic Targets·Olaf StüveScott S Zamvil
Mar 3, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shrutya BhallaAmteshwar Singh Jaggi
May 24, 2011·Pain·Luca MascitelliMark R Goldstein
Jul 27, 2005·Diabetes Care·Tom Brooks Vaughan, David S H Bell
Apr 4, 2017·British Journal of Clinical Pharmacology·Toke de Koning SvendsenDavid Gaist
Mar 31, 2006·Journal of Enzyme Inhibition and Medicinal Chemistry·Pathik S BrahmkshatriyaMahesh T Chhabria
Mar 8, 2013·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Daniel I Greenwood
Jun 7, 2018·Cardiology·Dominik Lautsch, Anselm K Gitt
Dec 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Connie B NewmanUNKNOWN American Heart Association Clinical Lipidology, Lipoprotein, Metabolism and Thrombosis Committee, a Joint Committee of the C
Aug 12, 2005·Muscle & Nerve·A Arturo LeisJake Olivier
Jul 9, 2008·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Lorne ZinmanAlex Kiss
Sep 11, 2019·Basic & Clinical Pharmacology & Toxicology·Toke de Koning SvendsenDavid Gaist
Sep 13, 2005·Current Opinion in Neurology·Thirugnanam Umapathi, Vinay Chaudhry
Jan 29, 2003·The Annals of Pharmacotherapy·James M Backes, Patricia A Howard
Nov 19, 2020·International Journal of Environmental Research and Public Health·So Young KimHyo Geun Choi
Feb 26, 2021·Journal of Clinical Pharmacy and Therapeutics·Miao WangYing Xie
Jun 15, 2007·Lancet·Jane Armitage
Oct 26, 2021·Muscle & Nerve·Thapat WannarongPatompong Ungprasert

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