Are volume-dependent parameters in positron emission tomography predictive of postoperative recurrence after resection in patients with thymic carcinoma?

Surgery Today
Masatsugu HamajiHiroshi Date

Abstract

This study aimed to investigate the association between the volume-dependent parameters in 18F-fluorodeoxyglucose-positron emission tomography (18F-FDG PET/CT) and a recurrence of thymic carcinoma. A retrospective chart review was performed based on our multi-institutional database to identify patients undergoing PET prior to resection of thymic carcinoma or neuroendocrine carcinoma between 1991 and 2018. The PET parameters (metabolic tumor volume and total lesion glycolysis) were evaluated retrospectively. The relevant factors were extracted and a survival analysis was performed using the Kaplan-Meier method. Sixteen patients were thus deemed to be eligible for analysis. The median follow-up period following resection was 2.65 years (range: 0.96-0.68 years). The recurrence-free survival was significantly longer in patients with a metabolic tumor volume <  = 22.755 cm3 and with total lesion glycolysis <  = 105.4006 g/mL (p = 0.001 and 0.001, respectively, by a log-rank test). The metabolic tumor volume and total lesion glycolysis may, therefore, be predictive of the postoperative recurrence of thymic carcinoma.

References

Oct 2, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Koichi FukumotoKohei Yokoi
Mar 1, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marcelo F K BenvenisteEdith M Marom
Apr 17, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Enrico RuffiniUNKNOWN European Society of Thoracic Surgeons Thymic Working Group
Jun 24, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Z Song, Y Zhang
Sep 2, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giorgio TregliaFilippo Lococo
Dec 20, 2014·The Journal of Thoracic and Cardiovascular Surgery·Usman AhmadAndreas Rimner
Jun 28, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tomoyuki HishidaUNKNOWN Japanese Association for Research on the Thymus (JART)
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N GirardUNKNOWN ESMO Guidelines Committee
Apr 4, 2017·The Annals of Thoracic Surgery·Masatsugu HamajiBryan M Burt
Feb 21, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Meinoshin OkumuraEtsuo Miyaoka
Mar 7, 2020·General Thoracic and Cardiovascular Surgery·UNKNOWN Committee for Scientific Affairs, The Japanese Association for Thoracic SurgeryYutaka Okita

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