Are voluntary wheel running and open-field behavior correlated in mice? Different answers from comparative and artificial selection approaches

Behavior Genetics
V CareauTheodore Garland

Abstract

Voluntary wheel running and open-field behavior are probably the two most widely used measures of locomotion in laboratory rodents. We tested whether these two behaviors are correlated in mice using two approaches: the phylogenetic comparative method using inbred strains of mice and an ongoing artificial selection experiment on voluntary wheel running. After taking into account the measurement error and phylogenetic relationships among inbred strains, we obtained a significant positive correlation between distance run on wheels and distance moved in the open-field for both sexes. Thigmotaxis was negatively correlated with distance run on wheels in females but not in males. By contrast, mice from four replicate lines bred for high wheel running did not differ in either distance covered or thigmotaxis in the open field as compared with mice from four non-selected control lines. Overall, results obtained in the selection experiment were generally opposite to those observed among inbred strains. Possible reasons for this discrepancy are discussed.

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Citations

Aug 15, 2014·Neurotoxicology·Stefanie L O'NealJason R Cannon
Oct 25, 2013·Evolution; International Journal of Organic Evolution·Vincent CareauTheodore Garland
Oct 27, 2012·Physiological and Biochemical Zoology : PBZ·Vincent Careau, Theodore Garland
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Feb 9, 2017·Frontiers in Physiology·Mindaugas KvedarasArimantas Lionikas
Nov 22, 2016·Journal of Neuroscience Research·Cheryl S Rosenfeld
Apr 1, 2021·Genes, Brain, and Behavior·Winona C BooherMarissa A Ehringer

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