PMID: 9437668Jan 23, 1998Paper

Area-dependent CNS membrane response of muscarinic receptor to convulsant 3-mercaptopropionic acid

Molecular and Chemical Neuropathology
P Schneider, G Rodriguez De Lores Arnaiz

Abstract

It has already been shown that the administration of convulsant 3-mercaptopropionic acid at 150 mg/kg enhances binding affinity of muscarinic antagonist [3H]quinuclidinyl benzilate ([3H]QNB) to certain rat CNS membranes without affecting site number. Herein we employed a 100 mg/kg dose and tested [3H]QNB binding to cerebellar, hippocampal, and striatal membranes obtained from rats killed at preseizure, seizure, and postseizure stages. In cerebellum, binding increased 24, 65, and 19% a1 preseizure, seizure, and postseizure stages, respectively; in hippocampus, values were 12 and 20% higher at pre- and seizure stages, but failed to differ from controls at postseizure; in striatum, increases of 10 and 18% were recorded at seizure and postseizure, with no changes at preseizure. Neither a subconvulsant dose (20 mg/kg) nor in vitro drug addition had any effect on binding. Results indicate a differential response to the convulsant, with reversible changes in cerebellum and hippocampus, and a delayed response in striatum, supporting the concept of area-dependent neuronal plasticity.

References

Sep 1, 1973·Journal of Neurochemistry· Rodríguez de Lores ArnM Mistrorigo de Pacheco
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H I Yamamura, S H Snyder
May 1, 1972·Journal of Neurochemistry· Rodríguez de Lores ArnE De Robertis
Feb 10, 1983·Nature·J W OlneyJ Labruyere
Jan 1, 1994·Molecular and Chemical Neuropathology·E GirardiG Rodriguez De Lores Arnaiz

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Citations

Apr 18, 2006·BMC Neuroscience·Patricia G Schneider, Georgina Rodríguez de Lores Arnaiz

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