Area of the pressure-strain loop during ejection as non-invasive index of left ventricular performance: a population study

Cardiovascular Ultrasound
Nicholas CauwenberghsTatiana Kuznetsova

Abstract

Previous studies highlighted the usefulness of integrating left ventricular (LV) deformation (strain) and hemodynamic parameters to quantify LV performance. In a population sample, we investigated the anthropometric and clinical determinants of a novel non-invasive index of LV systolic performance derived from simultaneous registration of LV strain and brachial pressure waveforms. Three hundred fifty-six randomly recruited subjects (44.7% women; mean age, 53.9 years; 47.5% hypertensive) underwent echocardiographic and arterial data acquisition. We constructed pressure-strain loops from simultaneously recorded two-dimensional LV strain curves and brachial pressure waveforms obtained by finger applanation tonometry. We defined the area of this pressure-strain loop during ejection as LV ejection work density (EWD). We reported effect sizes as EWD changes associated with a 1-SD increase in covariables. In multivariable-adjusted analyses, higher EWD was associated with age, female sex and presence of hypertension (P ≤ 0.0084). In both men and women, EWD increased independently with augmentation pressure (effect size: + 59.1 Pa), central pulse pressure (+ 65.7 Pa) and pulse wave velocity (+ 44.8 Pa; P ≤ 0.0006). In men, EWD decreased...Continue Reading

References

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Mar 13, 2018·European Heart Journal Cardiovascular Imaging·Arnaud HubertErwan Donal

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Citations

Apr 4, 2020·Artificial Organs·Louis S FixsenRichard G P Lopata
Aug 22, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yi-Lin ChenJi-Guang Wang

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Software Mentioned

SAS
GE Vingmed
Matlab
Finometer
EchoPac
SphygmoCor

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