Abstract
The effects of arginine vasopressin given into either the vertebral arteries, a peripheral vein (IV), or the cisterna magna of 15 morphine-chloralose anesthetized dogs were measured before and after pharmacological blockade with the antagonist [d(CH2)5 Tyr(Me) AVP]. The contribution of the area postrema to the pressor activity of vasopressin was assessed in nine other dogs by comparing the responses to vasopressin before and after surgical ablation of this structure. Administration of vasopressin either via the vertebral arteries or intravenously produced comparable gradual rises in blood pressure, accompanied by bradycardia and decreases in the plasma levels of norepinephrine. Administration of intracisternal vasopressin elicited a smaller rise in arterial pressure, tachycardia, and increases in plasma norepinephrine levels. The pressor and bradycardic effects of IV vasopressin were abolished when the antagonist was given via the same route. In contrast, intravertebral infusion of the vasopressin antagonist caused tachycardia and modest hypotension in response to intravenous or intravertebral infusions of vasopressin. Pressor effects of vasopressin given into the cisterna magna were not altered by systemic delivery of the vaso...Continue Reading
References
May 1, 1979·Hypertension·C M FerrarioK B Brosnihan
Nov 11, 1978·The American Journal of Physiology·J W Putney
Dec 1, 1985·Journal of Hypertension·C I Johnston
Feb 1, 1985·Endocrinology·A J Baertschi, M Friedli
Mar 1, 1985·Circulation Research·K P UndesserV S Bishop
Jul 1, 1984·Journal of Cardiovascular Pharmacology·J F Liard, J C Spadone
Nov 1, 1983·Hypertension·C M Ferrario
Nov 1, 1983·Hypertension·P A BridleC M Ferrario
Nov 1, 1983·Hypertension·L C MicheliniC M Ferrario
Jul 1, 1984·Hypertension·K L Barnes, C M Ferrario
Feb 1, 1981·Endocrinology·R D ZipserP Needleman
Nov 1, 1981·Neuropharmacology·G FeuersteinD M Jacobowitz
Mar 1, 1982·Endocrinology·Q J PittmanL McLean
Jul 1, 1982·Neuropharmacology·H MatsuguchiP G Schmid
Sep 1, 1981·Clinical Science·J F LiardJ Schoun
Sep 11, 1981·Science·S M ReppertD A Fisher
Citations
Nov 3, 1992·European Journal of Pharmacology·X ZhangW R Wooles
Apr 1, 1995·Drug and Alcohol Dependence·E Carmona-CaleroA Castañeyra-Perdomo
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·K YamamotoY Masuyama
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·C M FerrarioD B Averill
Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·T TsuchihashiM Fujishima
Feb 17, 2000·Annals of the New York Academy of Sciences·L C Michelini, M Morris
Apr 1, 1992·The Anatomical Record·A Castañeyra-PerdomoD J Heylings
Jan 1, 1991·Alcohol·A Castañeyra-PerdomoR Ferres-Torres
Jan 7, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L C Michelini
Feb 1, 1988·Hypertension·L C Michelini, L G Bonagamba