Area-specific representation of mechanical nociceptive stimuli within SI cortex of squirrel monkeys.

Pain
Li Min ChenAnna Wang Roe

Abstract

While functional imaging studies in humans have consistently reported activation of primary somatosensory cortex (SI) with painful stimuli, the specific roles of subdivisions of areas 3a, 3b, and 1 within SI during pain perception are largely unknown, particularly in the representation of mechanical evoked pain. In this study, we investigated how modality, location, and intensity of nociceptive stimuli are represented within SI by using high-spatial resolution optical imaging of intrinsic signals in Pentothal-anesthetized squirrel monkeys. Perceptually comparable mechanical nociceptive and innocuous tactile stimuli were delivered by indenting the glabrous skin of the distal finger pads with 0.2 and 2mm diameter probes, respectively. Within each of areas 3a, 3b, and 1, activations to mechanical nociceptive stimulation of individual distal finger pads were spatially distinct and somatotopically organized. We observed differential cortical activation patterns. Areas 3a, 3b, and 1 were all activated during mechanical nociceptive stimulation and were modulated by nociceptive stimulus intensity. However, with innocuous tactile stimulation, mainly areas 3b and 1 exhibited response modulation with different levels of stimulation. In su...Continue Reading

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Citations

Aug 29, 2013·Brain : a Journal of Neurology·Javeria A HashmiA Vania Apkarian
Oct 19, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li Min ChenJon H Kaas
Dec 4, 2010·Neuroscience and Biobehavioral Reviews·David Borsook, Lino Becerra
Jan 5, 2011·Neuropsychologia·Flavia ManciniPatrick Haggard
Dec 19, 2012·Pain·Charles J VierckMark Tommerdahl
May 27, 2010·Experimental Brain Research·Aurelio A AlonsoApostolos P Georgopoulos
Sep 13, 2013·Journal of Neurophysiology·Andrea A BrockAnna W Roe
Jul 28, 2020·NeuroImage·Rosa M Sanchez PanchueloOleg Favorov
Jun 3, 2021·Biomedicines·Myeong Seong BakSun Kwang Kim

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