Arf GTPase interplay with Rho GTPases in regulation of the actin cytoskeleton

Small GTPases
Vikash SinghVassilis Koronakis

Abstract

The Arf and Rho subfamilies of small GTPases are nucleotide-dependent molecular switches that act as master regulators of vesicular trafficking and the actin cytoskeleton organization. Small GTPases control cell processes with high fidelity by acting through distinct repertoires of binding partners called effectors. While we understand a great deal about how these GTPases act individually, relatively little is known about how they cooperate, especially in the control of effectors. This review highlights how Arf GTPases collaborate with Rac1 to regulate actin cytoskeleton dynamics at the membrane via recruiting and activating the Wave Regulatory Complex (WRC), a Rho effector that underpins lamellipodia formation and macropinocytosis. This provides insight into Arf regulation of the actin cytoskeleton, while putting the spotlight on small GTPase cooperation with emerging evidence of its importance in fundamental cell biology and interactions with pathogenic bacteria.

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Citations

Sep 4, 2020·International Journal of Molecular Sciences·Alazne Arrazola SastreJosé Luis Zugaza
Aug 30, 2017·Frontiers in Cellular and Infection Microbiology·Peter J HumeVassilis Koronakis
Apr 22, 2018·Biochemical Society Transactions·Claudia Hinze, Emmanuel Boucrot
Apr 8, 2020·International Journal of Molecular Sciences·Vikash SinghVassilis Koronakis
Oct 22, 2020·PeerJ·Wanwan CaiWuzhou Yuan
Aug 21, 2020·Molecular Aspects of Medicine·Juho VuononvirtaThanushiyan Poobalasingam
May 21, 2021·Journal of Cell Science·Mariana De NizCarolina Agop-Nersesian
Jul 21, 2021·Neural Development·Rebecca ShiKang Shen
Aug 27, 2021·Journal of Cell Science·Marius MusielakJürgen J Heinisch

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Methods Mentioned

BETA
GTPase
GTPases
nucleotide exchange
myristoylation

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