Arf1 and ER-mitochondrial tethering - a new trick for an old dog

The FEBS Journal
Dana A Davis

Abstract

Endoplasmic reticulum (ER)-mitochondria tethering by the ERMES complex is critical for numerous mitochondrial functions in fungi. It was recently discovered that the GTPase Arf1, which regulates within Golgi vesicular trafficking also affects ER-mitochondrial tethering potentially through ERMES. In Candida albicans, Arf1 not only functions in vesicular trafficking and affects ERMES but also impacts reactive oxygen species generation, which is a key immune defense molecule.

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