Arg-Ile-Tyr (RIY) derived from rapeseed protein decreases food intake and gastric emptying after oral administration in mice

Peptides
Ewa D MarczakMasaaki Yoshikawa

Abstract

We previously reported that a bioactive tripeptide Arg-Ile-Tyr (RIY), which has been isolated as an inhibitor for angiotensin I-converting enzyme from the subtilisin digest of rapeseed protein, decreased blood pressure. In this study, we also found that RIY dose-dependently decreased food intake at a dose of 150 mg/kg after oral administration in fasted ddY male mice. The anorexigenic action of RIY was blocked by a cholecystokinin-1 CCK1 receptor antagonist, lorglumide. RIY also decreased the gastric emptying rate at a dose of 150 mg/kg and the RIY-induced delay of gastric emptying was blocked by lorglumide. However, RIY had no affinity for CCK1 receptor. Taken together, RIY decreased food intake and gastric emptying by stimulating CCK release.

References

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Citations

Jul 29, 2011·Critical Reviews in Food Science and Nutrition·Janitha P D Wanasundara
Jul 25, 2012·Critical Reviews in Food Science and Nutrition·Ayyappan Appukuttan Aachary, Usha Thiyam
Jan 9, 2007·Peptides·Kousaku OhinataMasaaki Yoshikawa
Sep 5, 2012·Molecular Nutrition & Food Research·Tomomi KagebayashiKousaku Ohinata
Oct 10, 2013·Molecular Nutrition & Food Research·Noriyasu KontaniKousaku Ohinata
Jul 10, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kentaro KanekoKousaku Ohinata
May 6, 2020·Biotechnology and Bioengineering·Carolina GomesSandra I Vieira
Sep 11, 2020·Critical Reviews in Food Science and Nutrition·Anna ChmielewskaJustyna Rosicka-Kaczmarek
May 24, 2021·Peptides·Naohisa Shobako

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