Arg399Gln substitution in XRCC1 as a prognostic and predictive biomarker for prostate cancer: Evidence from 8662 subjects and a structural analysis

The Journal of Gene Medicine
Mahdi NoureddiniHossein Nikzad

Abstract

The Arg399Gln polymorphism in the X-ray repair cross-complementing group 1 gene (XRCC1) may alter the risk of prostate cancer (PCa). The present study aimed to investigate the association of the XRCC1-Arg399Gln polymorphism with PCa risk in an Iranian population, as followed by a meta-analysis and an in silico analysis. In a case-control study, 360 subjects were included (180 men with PCa and 180 healthy controls). XRCC1-Arg399Gln genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method. In the meta-analysis, 14 eligible studies were included to which our case-control data were added to estimate the pooled odds ratios. Some bioinformatics tools were employed to evaluate the effects of Arg399Gln substitution on molecular aspects of the XRCC1 protein. Our case-control study revealed a significant association between the XRCC1-Arg399Gln polymorphism and PCa risk. The data from overall meta-analysis showed significant associations between the mentioned polymorphism and PCa risk in allelic and recessive genetic models. In addition, we observed statistically significant associations in stratified analyses by ethnicity, sample size and source of controls. Our in silico analysis showe...Continue Reading

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Citations

Aug 5, 2019·Cellular and Molecular Life Sciences : CMLS·Erfaneh BaratiMohammad Karimian
May 31, 2019·Journal of Cellular Biochemistry·Hassan Hassani BafraniMohammad Karimian
Jul 28, 2020·Environmental Science and Pollution Research International·Mohammad KarimianAli Karimian
Sep 25, 2021·Expert Review of Molecular Diagnostics·Mohammad KarimianMohaddeseh Behjati

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