Argentine strain of equine herpesvirus 1 isolated from an aborted foetus shows low virulence in mouse respiratory and abortion models

Veterinary Microbiology
C M GalosiE J Gimeno

Abstract

The equine herpesvirus 1 (EHV-1) was isolated in Argentina from an aborted equine foetus in 1979. This virus (SPv) has special restriction patterns (RP) in comparison with other Argentine isolates. In addition, SPv could be distinguished on the basis of its pathogenicity in baby mice inoculated intracerebrally. We studied the growth properties of the SPv in cell culture and its effects in a mouse respiratory and abortion model. We observed that SPv did not modify its capacity to grow in cell culture with respect to reference HH1 strain. Nevertheless, we found significant differences between the titres of the two strains at 8-14 h post-infection (PI). In this work we demonstrated that SPv showed low virulence in female at different stages of gestation, consistently, with results found in the mouse respiratory model. We considered that this low virulence of SPv could be related to its RP because the RP of HH1 strain are similar to those of the HVS25A strain and both showed effect on pregnant mice. More specific studies about genomic alterations to the SPv are necessary for identifying, more clearly, if the intra-strain variations have relation with the low virulence in the mouse respiratory and abortion model.

References

Jul 1, 1992·Virology·E A TelfordA J Davison
Jul 1, 1991·Research in Veterinary Science·A R AwanH J Field
Jul 1, 1995·Journal of Virological Methods·P A van WoenselN Visser
Feb 1, 1995·Australian Veterinary Journal·H CsellnerD N Love
Jan 1, 1994·Archives of Virology·W A BonassI W Halliburton
Feb 1, 1993·The Journal of Veterinary Medical Science·M InazuH Iwai
Jan 1, 1993·Archives of Virology·R KirisawaY Kawakami
Sep 1, 1995·Research in Veterinary Science·A R AwanH J Field
Aug 12, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C M GalosiT Mikami
Mar 31, 1999·Journal of Comparative Pathology·C WalkerJ M Whalley
Jul 27, 2001·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·C M GalosiM E Etcheverrigaray

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Citations

Jul 16, 2013·Archives of Virology·Carolina ZanuzziCecilia Galosi
Jan 25, 2012·Virologica Sinica·Julian Ruiz-SaenzVictor Vera
Jun 22, 2011·Journal of Comparative Pathology·C M C MoriP C Maiorka
Jan 24, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Georg GosztonyiHanns Ludwig
Oct 26, 2006·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·C M GalosiE J Gimeno
Dec 29, 2005·Virology·Fernando CoboAngel Concha
Feb 6, 2013·Veterinary Pathology·M L EöryC G Barbeito

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