Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection

European Journal of Immunology
Sarah KnippenbergUlrich A Maus

Abstract

Type 2 helper cell (Th2) dominated chronic lung diseases such as asthma are characterized by an increased risk for bacterial lung infections. However, the underlying mechanisms are poorly defined. Arginase 1 (Arg1) has been suggested to play an important role in the pathophysiology of asthma, and is rapidly induced in lung macrophages by Th2 cytokines, thereby limiting macrophage-derived antimicrobial nitric oxide (NO) production. Here we examined the effect of Th2 cytokine induced upregulation or lung myeloid cell specific conditional knockdown of Arg1 on lung resistance against Streptococcus pneumoniae (Spn) in mice. Lung macrophages responded with a profound induction of Arg1 mRNA and protein to treatment with IL-13 both in vitro and in vivo. IL-13-induced Arg1 activity in the lungs of mice led to significantly attenuated lung-protective immunity against Spn, while conditional Arg1 knockdown had no effect on lung-protective immunity against Spn. Collectively, the data show that Th2 cytokine induced increased Arg1 activity worsens lung-protective immunity against Spn, and interventions to block Th2 cytokine induced lung Arg1 activity may thus be a novel immunomodulatory strategy to lower the risk of bacterial infections in as...Continue Reading

References

Jul 1, 1995·American Journal of Respiratory Cell and Molecular Biology·A J CoyleG P Anderson
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·J D MacMickingC F Nathan
Dec 11, 1997·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C MoserN Høiby
Dec 18, 1998·Science·M Wills-KarpD D Donaldson
Jan 6, 2000·Transgenic Research·B E ClausenI Förster
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
May 14, 2003·The Journal of Allergy and Clinical Immunology·Juan C ZambranoPeter W Heymann
Aug 19, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hong YuRamaswamy K Iyer
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefan El-GayarChristian Bogdan
Apr 9, 2004·American Journal of Respiratory and Critical Care Medicine·Claudia R MorrisSidney M Morris
May 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Helen M MarriottDavid H Dockrell
Sep 5, 2006·The Journal of Allergy and Clinical Immunology·Donald W Cockcroft, Beth E Davis
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine WinterUlrich A Maus
Sep 16, 2008·The Journal of Allergy and Clinical Immunology·Young J JuhnRobert M Jacobson
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Jul 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Renat ShaykhievRonald G Crystal
Aug 26, 2009·British Journal of Pharmacology·Harm MaarsinghHerman Meurs
Sep 22, 2009·British Journal of Pharmacology·Markus Munder
Oct 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathrin SteinwedeUlrich A Maus
May 4, 2012·The Journal of Allergy and Clinical Immunology·Natalie E NieuwenhuizenFrank Brombacher

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Citations

Nov 27, 2015·Current Opinion in Microbiology·Mayuri GogoiDipshikha Chakravortty
Feb 19, 2016·European Journal of Immunology·Hye Young KimRosemarie H Dekruyff
Jul 22, 2017·Molecular Medicine Reports·Luo-Qin FuWei-Fen Li
Jun 21, 2020·Clinical and Experimental Immunology·J WieczfinskaR Pawliczak
Jul 7, 2017·Frontiers in Cellular and Infection Microbiology·Kenny BielenSamir Kumar-Singh

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