Arginine CGA codons as a source of nonsense mutations: a possible role in multivariant gene expression, control of mRNA quality, and aging

Molecular Genetics and Genomics : MGG
Georgy A Romanov, Victor S Sukhoverov

Abstract

Methylation of cytosine residues in DNA of higher eukaryotes, including humans, creates "hot spots" of C→T transitions in the genome. The predominantly methylated sequence in mammalian DNAs is CG (CpG). Among CG-containing codons, CGA codons for arginine are unique due to their ability to create stop codons TGA (UGA in mRNA) upon epigenetic-mediated mutation. As such nonsense mutations can have a strong adverse effect on the cell and organism, we have performed a study, on the example of human genes, aimed to characterise the anticipated effects of epigenetic-mediated nonsense mutations CGA→TGA in somatic cells. It is commonly accepted that premature termination codons (PTCs) lead to the biosynthesis of truncated and usually inactive proteins. In addition, transcripts with PTC can be destroyed by a nonsense-mediated mRNA decay (NMD) machinery. We have considered the cell potentialities (gene families, diploidy, and alternative splicing) to overcome the worst consequences of nonsense mutation. As a special case, in the biosynthesis of a particular group of proteins called selenoproteins, the mutation CGA→UGA would not lead to the premature translation termination and NMD but rather to the insertion of selenocysteine or cysteine ...Continue Reading

References

Sep 1, 1989·Human Genetics·D N Cooper, M Krawczak
Feb 1, 1988·Human Genetics·D N Cooper, H Youssoufian
Apr 1, 1986·Bioscience Reports·M EhrlichC W Gehrke
Apr 11, 1980·Nucleic Acids Research·A P Bird
Jul 31, 1998·American Journal of Human Genetics·M KrawczakD N Cooper
May 31, 2003·Science·Gregory V KryukovVadim N Gladyshev
Dec 6, 2003·Genome Research·Pablo D RabinowiczRobert A Martienssen
Jun 14, 2005·Biochemistry. Biokhimii︠a︡·B F Vanyushin
Nov 24, 2005·Nature Reviews. Genetics·Valter D LongoVladimir P Skulachev
Jun 8, 2006·European Journal of Human Genetics : EJHG·Mehrdad KhajaviJames R Lupski
Oct 31, 2006·Nature Genetics·Florian EckhardtStephan Beck
May 6, 2008·Human Mutation·Matthew MortNadia A Chuzhanova
Nov 6, 2008·Journal of Molecular Biology·Vincent PetitJean-Pierre Vartanian
Dec 3, 2008·Advances in Physiology Education·Rodney A HillJennifer M Pell
May 26, 2009·Ageing Research Reviews·Alexander L Mazin
Mar 8, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Elizabeth A Mazzio, Karam F A Soliman
Jun 29, 2012·Molecular Genetics and Genomics : MGG·Andigoni Malousi, Sofia Kouidou
Feb 28, 2013·Frontiers in Genetics·Stefanie Wolters, Björn Schumacher
Mar 20, 2013·Frontiers in Genetics·Lucas S TrindadeJonathan G Heddle
Jul 16, 2013·Nature Genetics·Michael B BurnsReuben S Harris
Nov 28, 2013·Annual Review of Genetics·Maximilian Wei-Lin Popp, Lynne E Maquat
Jul 6, 2014·Physiological Reviews·Vyacheslav M LabunskyyVadim N Gladyshev
Sep 25, 2014·Protein Science : a Publication of the Protein Society·N SchormannD Chattopadhyay
Dec 18, 2014·RNA·Vipender SinghJohn M Essigmann
Sep 19, 2015·Oncotarget·Brandon MilhollandJan Vijg
Jan 21, 2016·Journal of Cell Science·Tatsuaki Kurosaki, Lynne E Maquat
Jun 15, 2016·International Journal of Analytical Chemistry·Elena A PonomarenkoAlexander I Archakov
Aug 16, 2016·Nature Communications·Dmitriy I PodolskiyVadim N Gladyshev

❮ Previous
Next ❯

Citations

Jul 23, 2020·Molecular Genetics & Genomic Medicine·Konark MukherjeeSarika Srivastava
Feb 2, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Magy SallamAn Aerts
Mar 11, 2021·Molecular and Cellular Endocrinology·Cintia E CitterioHéctor M Targovnik
Jun 14, 2021·Molecular and Cellular Endocrinology·Mauricio Gomes PioHéctor M Targovnik

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination
gene knockout

Software Mentioned

Excel
EPIMUT3
Infernal
Covels

Related Concepts

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Related Papers

Trends in Genetics : TIG
Saverio BrognaMarija Petric
Mutation Research. Reviews in Mutation Research
Jake N Miller, David A Pearce
Biochemical Society Transactions
Fursham M Hamid, Eugene V Makeyev
AIDS Research and Human Retroviruses
Vincent MocquetPierre Jalinot
© 2022 Meta ULC. All rights reserved