Arginine deiminase enhances dexamethasone-induced cytotoxicity in human T-lymphoblastic leukemia CCRF-CEM cells

International Journal of Cancer. Journal International Du Cancer
Eun-Joo NohBon Hong Min

Abstract

Since arginine deiminase (ADI; EC 3.5.3.6) inhibits cell proliferation by arresting cells in the G1 phase, we tested its synergistic effect on cell death induced by dexamethasone (DEX), which also induces apoptosis by G1 cell cycle arrest. ADI inhibited cell proliferation and induced apoptosis in human leukemic CEM cells in a dose-dependent manner. Simultaneous treatment with ADI and DEX showed synergistic effects on DNA fragmentation and LDH release. In addition, ADI exerted its anti-proliferative activity against DEX-resistant CEM cells. ADI suppressed expression of c-myc, a potential key regulator of cell proliferation and apoptosis, and increased expression of p27Kip1 cyclin-dependent kinase inhibitor. These results suggest that ADI efficiently increases the anti-cancer effect of DEX on human leukemic CEM cells through G1 cell cycle arrest involving downregulation of c-myc and upregulation of p27Kip1.

References

Feb 1, 1979·Journal of Cellular Physiology·J M HarmonE B Thompson
May 8, 1992·International Journal of Cancer. Journal International Du Cancer·H TakakuK Miyazaki
Jan 1, 1997·Experimental Parasitology·L A KnodlerM R Edwards
Feb 1, 1997·International Journal of Hematology·Y KomadaE Azuma
May 1, 1997·The Annals of Pharmacotherapy·L M Holle
Nov 10, 1998·The Biochemical Journal·G Wu, S M Morris
Dec 8, 1998·Pediatric Hematology and Oncology·S SahuS H Advani
Jul 16, 1999·Biochemical and Biophysical Research Communications·H GongL Schweigerer
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·E B ThompsonB H Johnson
Dec 10, 1999·Immunopharmacology and Immunotoxicology·H O PaeH T Chung
Jun 10, 2000·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·D N WheatleyS Smith
Mar 12, 2002·Advances in Cancer Research·Sara K OsterLinda Z Penn
Apr 2, 2002·Neoplasia : an International Journal for Oncology Research·Aaron L MillerE Brad Thompson
Jun 18, 2002·Cancer Letters·Karin BeloussowWei Chiang Shen
Jul 17, 2003·International Journal of Cancer. Journal International Du Cancer·Hong GongLothar Schweigerer
Aug 28, 2003·British Journal of Cancer·I-S ParkB-H Min

❮ Previous
Next ❯

Citations

Aug 23, 2005·Cancer Letters·Denys N WheatleyElaine Campbell
Jan 8, 2013·Clinical Pharmacology : Advances and Applications·Jung-Ki YoonKevin B Kim
Jun 6, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Lihua LiHaifeng Song
Jul 21, 2014·Enzyme and Microbial Technology·Keum-Young AhnJeewon Lee
Jun 22, 2006·Expert Opinion on Investigational Drugs·Lynn Feun, Niramol Savaraj
Nov 11, 2006·International Journal of Cancer. Journal International Du Cancer·Cheol-Yong YoonBon-Hong Min
Apr 29, 2015·Cancer Letters·Fuming QiuMeihua Sui
Oct 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paolo A AsciertoTheodore F Logan
Apr 16, 2019·Expert Review of Molecular Diagnostics·Giuseppe LucarelliMichele Battaglia
Dec 24, 2018·Apoptosis : an International Journal on Programmed Cell Death·Lucy E MétayerGuy C Brown
Jul 25, 2021·Cancers·Chia-Lin ChenHsing-Jien Kung
Jul 25, 2021·International Journal of Molecular Sciences·Chunjing WuNiramol Savaraj
Jul 27, 2021·Cancer Chemotherapy and Pharmacology·Neha Kumari, Saurabh Bansal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis