Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications

International Journal of Molecular Sciences
Gerrit M GrosseChi-Un Choe

Abstract

The amino acid L-arginine serves as substrate for the nitric oxide synthase which is crucial in vascular function and disease. Derivatives of arginine, such as asymmetric (ADMA) and symmetric dimethylarginine (SDMA), are regarded as markers of endothelial dysfunction and have been implicated in vascular disorders. While there is a variety of studies consolidating ADMA as biomarker of cerebrovascular risk, morbidity and mortality, SDMA is currently emerging as an interesting metabolite with distinct characteristics in ischemic stroke. In contrast to dimethylarginines, homoarginine is inversely associated with adverse events and mortality in cerebrovascular diseases and might constitute a modifiable protective risk factor. This review aims to provide an overview of the current evidence for the pathophysiological role of arginine derivatives in cerebrovascular ischemic diseases. We discuss the complex mechanisms of arginine metabolism in health and disease and its potential clinical implications in diverse aspects of ischemic stroke.

References

Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Nov 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·R BusseE Bassenge
Feb 1, 1987·Archives of Biochemistry and Biophysics·T OgawaK Sasaoka
Nov 11, 1995·The American Journal of Physiology·F M FaraciD D Heistad
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C IadecolaN A Lassen
Jun 1, 1997·Stroke; a Journal of Cerebral Circulation·A F SamdaniV L Dawson
Feb 1, 1997·Nitric Oxide : Biology and Chemistry·E I ClossU Förstermann
Oct 8, 1999·Stroke; a Journal of Cerebral Circulation·G SegarraD A Pelligrino
Nov 26, 1999·Acta Physiologica Scandinavica·S A FicklingG S Whitley
Dec 11, 2003·Atherosclerosis. Supplements·Karsten Sydow, Thomas Münzel
Mar 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·I V SmirnovaM S Goligorsky
Jun 17, 2004·Circulation·Jean Davignon, Peter Ganz
Oct 14, 2004·Endocrine Reviews·David Y LeeMichael R Stallcup
Nov 24, 2004·Clinical and Experimental Pharmacology & Physiology·Tmc BruniniAc Mendes-Ribeiro
Feb 17, 2006·Journal of the American Society of Nephrology : JASN·Stefanie M Bode-BögerHolger Reinecke
Jul 1, 2006·Stroke; a Journal of Cerebral Circulation·Jan T KielsteinStefanie M Bode-Böger
Dec 13, 2006·American Journal of Respiratory Cell and Molecular Biology·Sandra M Wells, Andrij Holian
Dec 15, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carmine ZoccaliRainer Boger
Dec 22, 2006·European Journal of Clinical Investigation·M GuazziM D Guazzi
Feb 28, 2007·Archives of Internal Medicine·Jan HeeringaJacqueline C M Witteman
Apr 3, 2007·Biochemical and Biophysical Research Communications·Qiong YuanYuan-Jian Li
Apr 28, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jun-Lin JiangYuan-Jian Li
May 19, 2007·Stroke; a Journal of Cerebral Circulation·Kazushi Tsuda
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Parveen A RashidPhilip M W Bath
Oct 25, 2007·Biochemical Society Transactions·S Murphy, C L Gibson
Nov 2, 2007·Clinical and Experimental Pharmacology & Physiology·Luisa R de MeirellesTatiana M C Brunini
Aug 22, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kumiko FurukiTsutomu Imaizumi
Dec 9, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eva SchepersRaymond Vanholder

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Citations

Jan 30, 2021·Neural Regeneration Research·Mushfiquddin KhanJeseong Won
Jan 31, 2021·Vaccines·Joel MintzHimanshu Arora

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Methods Mentioned

BETA
percutaneous angioplasty

Clinical Trials Mentioned

NCT03692234

Software Mentioned

NAVIGATE

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