Arginine Metabolism and Its Potential in Treatment of Colorectal Cancer.

Frontiers in Cell and Developmental Biology
Tao Du, Junyi Han

Abstract

Colorectal cancer is the leading cause of death from cancer globally. The current treatment protocol still heavily relies on early detection and surgery. The molecular mechanisms underlying development of colorectal cancer are clinically important and determine the prognosis and treatment response. The arginine metabolism pathway is hyperactive in colorectal cancer and several molecules involved in the pathway are potential targets for chemoprevention and targeted colorectal cancer therapy. Endothelial nitric oxide synthase (eNOS), argininosuccinate synthetase and ornithine decarboxylase (ODC) are the main enzymes for arginine metabolism. Limiting arginine-rich meat consumption and inhibiting ODC activity largely reduces polyamine synthesis and the incidence of colorectal cancer. Arginine transporter CAT-1 and Human member 14 of the solute carrier family 6 (SLC6A14) are overexpressed in colorectal cancer cells and contributes to intracellular arginine levels. Human member 9 of the solute carrier family 38 (SLC38A9) serves as a component of the lysosomal arginine-sensing machinery. Pharmaceutical inhibition of single enzyme or arginine transporter is hard to meet requirement of restoring of abnormal arginine metabolic network. A...Continue Reading

References

Jan 1, 1996·Annual Review of Biochemistry·M S Malandro, M S Kilberg
Jan 1, 1997·Annual Review of Immunology·J MacMickingC Nathan
Oct 28, 1998·Physiological Reviews·M PalacínA Zorzano
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paulo C RodriguezAugusto C Ochoa
Apr 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew I SuJohn B Hogenesch
Oct 29, 2004·Nature Reviews. Cancer·Eugene W Gerner, Frank L Meyskens
May 21, 2005·Biochimica Et Biophysica Acta·Naren GuptaVadivel Ganapathy
Jun 17, 2006·Cell·Suvendra N BhattacharyyaWitold Filipowicz
Jun 24, 2006·Nature Reviews. Cancer·Dai FukumuraRakesh K Jain
Oct 7, 2006·Blood·Paulo C RodriguezAugusto C Ochoa
Apr 10, 2007·The Journal of Membrane Biology·E I ClossA Rotmann
Jun 5, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Zhenguo LiuRobert J Bache
Dec 21, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qingyong MaZhengjun Song
Jan 31, 2008·JAMA : the Journal of the American Medical Association·Aaron J SchetterCurtis C Harris
Mar 18, 2008·Nature·Kian-Huat LimChristopher M Counter
May 14, 2008·Current Pharmaceutical Design·L FeunN Savaraj
Nov 26, 2008·Amino Acids·Guoyao WuYulong Yin
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·S E ErdmanJ G Fox
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eugene W Gerner, Frank L Meyskens
Jun 10, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Melissa M CenterElizabeth Ward
Oct 1, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicholas F Evageliou, Michael D Hogarty
Oct 31, 2009·International Journal of Cancer. Journal International Du Cancer·Zhaohui HuangXiang Du
Nov 10, 2009·CA: a Cancer Journal for Clinicians·Melissa M CenterElizabeth Ward
Dec 25, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nurit Yachimovich-CohenBenjamin Reubinoff
Jan 28, 2010·International Journal of Cancer. Journal International Du Cancer·Barbara DelagePeter W Szlosarek
Mar 23, 2010·Lancet·David CunninghamNaureen Starling
Aug 19, 2010·Science Signaling·Sidney M Morris
Aug 27, 2010·Journal of Surgical Oncology·Jung-Cheng KangYi-Shing Shieh
Oct 6, 2010·Gut·Colin C Pritchard, William M Grady

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Aug 24, 2021·Journal of Inorganic Biochemistry·Kamila Stokowa-SołtysKarolina Jagiełło

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