Arginine metabolism in Trichomonas vaginalis infected with Mycoplasma hominis.

Microbiology
Mary MoradaNigel Yarlett

Abstract

Both Mycoplasma hominis and Trichomonas vaginalis utilize arginine as an energy source via the arginine dihydrolase (ADH) pathway. It has been previously demonstrated that M. hominis forms a stable intracellular relationship with T. vaginalis; hence, in this study we examined the interaction of two localized ADH pathways by comparing T. vaginalis strain SS22 with the laboratory-generated T. vaginalis strain SS22-MOZ2 infected with M. hominis MOZ2. The presence of M. hominis resulted in an approximately 16-fold increase in intracellular ornithine and a threefold increase in putrescine, compared with control T. vaginalis cultures. No change in the activity of enzymes of the ADH pathway could be demonstrated in SS22-MOZ2 compared with the parent SS22, and the increased production of ornithine could be attributed to the presence of M. hominis. Using metabolic flow analysis it was determined that the elasticity of enzymes of the ADH pathway in SS22-MOZ2 was unchanged compared with the parent SS22; however, the elasticity of ornithine decarboxylase (ODC) in SS22 was small, and it was doubled in SS22-MOZ2 cells. The potential benefit of this relationship to both T. vaginalis and M. hominis is discussed.

References

Apr 1, 1976·Journal of Bacteriology·J D Fenske, G E Kenny
Aug 1, 1990·International Journal for Parasitology·P J SchofieldW J O'Sullivan
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A J DriessenW Konings
Oct 1, 1986·Molecular and Biochemical Parasitology·P N Lowe, A F Rowe
Jul 1, 1983·Molecular and Biochemical Parasitology·D Linstead, M A Cranshaw
Mar 1, 1982·The Journal of Infectious Diseases·K C ChenK K Holmes
Jul 15, 1993·The Biochemical Journal·N YarlettC J Bacchi
Jun 1, 1996·Molecular and Biochemical Parasitology·N YarlettJ Tachezy
Oct 27, 1998·Lancet·P RappelliP L Fiori
Mar 10, 2004·Applied and Environmental Microbiology·Ann GriswoldRobert A Burne
Apr 29, 2004·Journal of the American Chemical Society·Xuefeng LuDebra Dunaway-Mariano
Jan 16, 2007·Science·Jane M CarltonPatricia J Johnson
Mar 25, 2008·Molecular and Biochemical Parasitology·Emma RingqvistStaffan G Svärd
Aug 14, 2008·Journal of Cell Science·Maria Carolina TouzTheodore Elliott Nash

❮ Previous
Next ❯

Citations

May 23, 2013·Sexually Transmitted Infections·Robert P Hirt
Aug 15, 2015·International Journal of Molecular Sciences·Dashuang ShiMendel Tuchman
Dec 2, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·K KubiakE Dzika
Jan 26, 2018·Parasitology Research·Ursula FürnkranzJulia Walochnik
Jan 9, 2019·Parasitology·Daniele DessìPaola Rappelli
Jun 23, 2018·Poultry Science·Gavin BoerboomAdriano Pérez-Bonilla
Jul 14, 2017·Frontiers in Microbiology·Anastasios IoannidisStylianos Chatzipanagiotou
Apr 4, 2017·Research in Microbiology·Raina FichorovaPier Luigi Fiori

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

psort
BioEdit
RAM
TargetP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases
Pin-Jia Wang, Cheng-Bin Xie
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases
Shun-li FangZhao-rong Lun
© 2021 Meta ULC. All rights reserved