Arginine Metabolism Is Altered in Adults with A-β + Ketosis-Prone Diabetes

The Journal of Nutrition
Surya N MulukutlaAshok Balasubramanyam

Abstract

A-β + ketosis-prone diabetes (KPD) is a subset of type 2 diabetes in which patients have severe but reversible β cell dysfunction of unknown etiology. Plasma metabolomic analysis indicates that abnormal arginine metabolism may be involved. The objective of this study was to determine the relation between gut microbiome and arginine metabolism and the relation between arginine availability and β cell function in KPD patients compared with control participants. Kinetics of arginine and related metabolites were measured with stable isotope tracers, and insulin secretory responses to arginine and glucose were determined under euglycemic and hyperglycemic conditions in 6 KPD patients and 6 age-, gender-, and body mass index-matched control participants. Glucose potentiation of arginine-induced insulin secretion was performed in a different set of 6 KPD and 3 control participants. Arginine availability was higher in KPD patients during euglycemia [53.5 ± 4.3 (mean ± SEM) compared with 40.3 ± 2.4 μmol · kg lean body mass (LBM)-1 · h-1, P = 0.03] but declined more in response to hyperglycemia (Δ 10.15 ± 2.6 compared with Δ 3.20 ± 1.3 μmol · kg LBM-1 · h-1, P = 0.041). During hyperglycemia, ornithine flux was not different between group...Continue Reading

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Citations

Jan 8, 2019·Expert Review of Endocrinology & Metabolism·Ruchi GabaAshok Balasubramanyam
Aug 11, 2020·BMJ Open Diabetes Research & Care·Åke Sjöholm
Mar 1, 2018·The Journal of Nutrition·Michael S Boyne
Oct 17, 2020·Annual Review of Medicine·Ashok Balasubramanyam
Jul 23, 2021·The Journal of Clinical Endocrinology and Metabolism·Maria J Redondo, Ashok Balasubramanyam

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