Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria.

Current Opinion in Infectious Diseases
J Brice WeinbergDonald L Granger

Abstract

Parasiticidal therapy of severe falciparum malaria improves outcome, but up to 30% of these patients die despite best therapy. Nitric oxide is protective against severe disease, and both nitric oxide and arginine (the substrate for nitric oxide synthase) are low in clinical malaria. Parasitized red blood cell interactions with endothelium are important in the pathophysiology of malaria. This review describes new information regarding nitric oxide, arginine, carbon monoxide, and endothelial function in malaria. Low arginine, low nitric oxide production, and endothelial dysfunction are common in severe malaria. The degree of hypoargininemia and endothelial dysfunction (measured by reactive hyperemia-peripheral artery tonometry) is proportional to parasite burden and severity of illness. Plasma arginase (an enzyme that catabolizes arginine) is elevated in severe malaria. Administering arginine intravenously reverses hypoargininemia and endothelial dysfunction. The cause(s) of hypoargininemia in malaria is unknown. Carbon monoxide (which shares certain functional properties with nitric oxide) protects against cerebral malaria in mice. Replenishment of arginine and restoration of nitric oxide production in clinical malaria should di...Continue Reading

References

Nov 1, 1979·Annals of Surgery·H FreundJ E Fischer
Sep 1, 1991·Infection and Immunity·K A RockettI A Clark
Jan 1, 1991·Infection·J E Fowler
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
May 1, 1995·Metabolism: Clinical and Experimental·Y M YuJ F Burke
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L CastilloV R Young
Aug 1, 1998·Journal of Inherited Metabolic Disease·R IyerS Cederbaum
Aug 26, 1998·The Journal of Biological Chemistry·Y XiaJ L Zweier
Dec 2, 1998·British Journal of Clinical Pharmacology·S M Bode-BögerJ C Frölich
Dec 13, 2000·The Journal of Pediatrics·R M BeckerJ M Rhoads
Dec 21, 2000·British Journal of Haematology·C R MorrisL A Styles
Feb 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·Y M YuV R Young
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·R H Böger, S M Bode-Böger
Aug 28, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S H Snyder, D E Barañano
Nov 12, 2002·Nature Medicine·Christopher D ReiterMark T Gladwin
Dec 19, 2002·Trends in Parasitology·Philippe VincendeauM Djavad Mossalayi
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Feb 11, 2003·Critical Care Medicine·Zvi ArgamanLeticia Castillo
Mar 11, 2003·American Journal of Respiratory and Critical Care Medicine·Claudia R MorrisElliott P Vichinsky
Apr 23, 2003·The American Journal of Pathology·Supattra SeriromMay Ho
Jan 28, 2004·Nature Medicine·Terrie E TaylorJeffrey G Mueller
Apr 7, 2005·JAMA : the Journal of the American Medical Association·Russell P RotherMark T Gladwin
Apr 22, 2005·Biological Chemistry·Ingrid B MüllerCarsten Wrenger
May 20, 2005·American Journal of Respiratory and Critical Care Medicine·Danielle Morse, Augustine M K Choi
Jul 7, 2005·JAMA : the Journal of the American Medical Association·Claudia R MorrisMark T Gladwin
Aug 30, 2005·Lancet·Arjen DondorpUNKNOWN South East Asian Quinine Artesunate Malaria Trial (SEAQUAMAT) group
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Steven P SchulmanGary Gerstenblith
Jul 1, 2006·Current Opinion in Critical Care·Andre C Kalil, Robert L Danner
Nov 14, 2006·Nature Medicine·Irene GramagliaHenri C van der Heyde
Mar 14, 2007·Circulation·John E DeanfieldTon J Rabelink

❮ Previous
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Citations

Oct 28, 2009·Human Genetics·Marc C LevesqueJ Brice Weinberg
Dec 9, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S Balachandar, A Katyal
Apr 7, 2009·Nature Reviews. Neurology·Saroj K Mishra, Charles R J C Newton
Jul 29, 2010·The Journal of Infectious Diseases·Jacqueline J JankaDonald J Krogstad
Nov 1, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Sidney M Morris
Mar 23, 2011·Current Opinion in Hematology·Hani KimKevin C Kain
Jun 29, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Sarah MurphyWalter Dzik
Nov 26, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Ivo M B FrancischettiMichael Waisberg
May 23, 2013·PLoS Pathogens·Steve M TaylorRick M Fairhurst
May 1, 2012·Journal of Neuroparasitology·Sarah Hochman, Kami Kim
Mar 13, 2014·The Journal of Infectious Diseases·Joe Brice WeinbergNicholas M Anstey
Mar 6, 2012·Revue neurologique·F GayA Moreno
Jan 5, 2011·Research in Veterinary Science·Fu ShixinLi Xiaobing
Mar 26, 2010·Trends in Parasitology·Leonardo J M Carvalho
Sep 15, 2009·Trends in Parasitology·Michele LeRouxJohanna P Daily
Jul 22, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K KanchanS Habib
Mar 31, 2012·Virulence·Laurent RéniaLisa F P Ng
Aug 2, 2018·BMC Research Notes·Ed Carlos Rey MouraRioko Kimiko Sakata
Jul 31, 2013·Infection and Immunity·Jörg H Fritz
Feb 3, 2016·Infection and Immunity·Ana Carolina A V KayanoFabio T M Costa
Jul 9, 2010·Current Opinion in Infectious Diseases·Danny A Milner
May 21, 2013·Pathogens and Global Health·Anthony R Mawson
Sep 3, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Timothy PlanchePeter G Kremsner
May 13, 2009·Current Opinion in Neurology·Saroj K Mishra, Lothar Wiese
May 1, 2019·Scientific Reports·Stije J LeopoldArjen M Dondorp
Oct 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tsin W YeoJ Brice Weinberg
Sep 8, 2010·Expert Review of Anti-infective Therapy·Chandy C JohnRobert O Opoka
Aug 29, 2018·Scientific Reports·Ornella CominettiCliment Casals-Pascual
May 10, 2018·Frontiers in Immunology·Aleksandra LeligdowiczKevin C Kain

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