PMID: 6977654Nov 1, 1981Paper

Arginine stimulates thymic immune function and ameliorates the obesity and the hyperglycemia of genetically obese mice

JPEN. Journal of Parenteral and Enteral Nutrition
A BarbulE Seifter

Abstract

The effect of 6-day dietary arginine supplementation on the weight gain, blood glucose, thymus weight, thymic lymphocyte content, and in vitro thymic lymphocyte immune reactivity was studied in obese (C57BL/6J-OB/)B) and heterozygous lean mice. Control mice were fed a commercial laboratory chow (1.8% arginine content) and drank tap water, while supplemented mice were given 0.5% arginine in the chow and 0.5% arginine solution for drinking. All mice ate and drank ad libitum. Supplemental arginine significantly decreased the weight gain (1.2 g vs. 2.2 g, p less than 0.01) and blood glucose levels (303 mg% vs 236 mg%, p less than 0.02) of the OB/OB mice; no such effects were noted in the lean heterozygotes, all of which had normal blood glucose levels. OB/OB mice had thymus glands which weighed less and contained significantly fewer lymphocytes than their lean littermates. In vitro mitogen-stimulated thymic lymphocyte protein synthetic rates were equal in chow-fed lean and OB/OB mice. In both groups, supplemental arginine significantly increased thymus weight, the number of thymic lymphocytes per gland, and thymic lymphocyte immunoreactivity in vitro. The hormonal secretagogue activity of arginine on the pituitary may explain its b...Continue Reading

References

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Sep 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·A BarbulG Efron

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Citations

Aug 1, 1992·Digestive Diseases and Sciences·S A McClaveH L Snider
Aug 1, 1983·Biological Trace Element Research·F H NielsenW E Cornatzer
Sep 27, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·P Fürst
Oct 27, 2011·The Kurume Medical Journal·Kazuhiro MikagiShigeaki Aoyagi
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·R FaggioniG Fantuzzi
Jan 1, 1992·World Journal of Surgery·J P Waymack, D N Herndon
Mar 8, 2008·Regulatory Toxicology and Pharmacology : RTP·Andrew Shao, John N Hathcock
Dec 1, 2004·JPEN. Journal of Parenteral and Enteral Nutrition·Vishal BansalJuan B Ochoa
Mar 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·A Barbul
Sep 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·S J Kirk, A Barbul
Jan 27, 2006·World Journal of Gastroenterology : WJG·Huey-Fang ShangSung-Ling Yeh
Oct 7, 2006·Blood·Paulo C RodriguezAugusto C Ochoa

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