PMID: 2112635May 1, 1990Paper

Arginine supplementation and its effect on established peritonitis in guinea pigs

JPEN. Journal of Parenteral and Enteral Nutrition
S J GonceP W Miskell

Abstract

To evaluate the efficacy of supplemental arginine with nutritional support in the presence of sepsis, eighty-eight gastrostomized female Hartley guinea pigs were implanted with osmotic pumps effusing an Eschericia coli/Staphylococcus aureus mixture. Animals were randomized and infused for two weeks with isocaloric and isovolumetric diets containing 0%, 2%, 4%, or 6% supplemental arginine as arginine hydrochloride. Survival was 12/22 (54%) in 0%, 9/22 (41%) in 2% and 4%, and 2/22 (9%) in 6%. Analysis by chi-square test of independence was significant (p = 0.0141) with 6% survival lower than the others. Median survival was 11 days in 0%, 8 days in 2% and 6%, and 9 days in 4%. Median survival was longer in 0% than in 2% or 6% (Kruskal-Wallis ANOVA: p = 0.02). Nitrogen balance was significantly lower in 6% compared to 0% on days 2 through 10, and lower than 2% and 4% on days 6 and 9. Nitrogen balance was higher in 0% than in 2% on days 4, 6, 10, and 13. Serum albumin and C3 were lower in all experimental groups than normal controls (ANOVA: p = 0.01). Comparison of liver, spleen, adrenals, gastrocnemius, and carcass weights, cell-mediated immunity as determined by contact sensitivity to DNFB, and transferrin showed no significant di...Continue Reading

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Citations

Feb 25, 2010·Pediatric Surgery International·Hui-Chen LoChien-Hsing Lee
Aug 7, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Huey-Fang ShangSung-Ling Yeh
Dec 31, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Carmelo Nieves, Bobbi Langkamp-Henken
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Oct 16, 2004·Critical Care Medicine·Yvette C LuikingNicolaas E Deutz
Apr 1, 1997·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·R G Barton
Sep 18, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Joseph F PierreKenneth A Kudsk
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