Arginine vasopressin and baroreflex function after converting enzyme inhibition in normal humans

The American Journal of Physiology
S R Goldsmith

Abstract

Arginine vasopressin (AVP) has been shown to interact with sinoaortic and cardiac reflexes under selected experimental conditions. In humans, there is no evidence that AVP potentiates reflex function at modestly increased plasma levels, except possibly if the angiotensin-converting enzyme (ACE) is inhibited. The objective of this study was to test the hypothesis that a modest physiological increase in plasma AVP would potentiate the responses of heart rate (HR), forearm vascular resistance (FVR), plasma norepinephrine (NE), or systemic NE spillover to baroreflex unloading and loading after pretreatment with lisinopril in healthy human volunteers. Seven normal young men were studied on three occasions. Baseline HR, FVR, and steady-state NE kinetics were established, and AVP or vehicle (5% dextrose in water) was infused for 15 min double-blind on the first 2 days. Baroreflexes were then perturbed as follows: 15 min 60 degrees head-up tilt, 15 min 30 degrees head-down tilt plus 1,000 ml normal saline infusion, 15 min 30 degrees head-down tilt plus phenylephrine titrated to raise mean arterial pressure 10-15 mmHg. The study was repeated on a third day 12 h after 5 mg of lisinopril. Five additional subjects underwent similar baroref...Continue Reading

References

Mar 1, 1988·British Journal of Clinical Pharmacology·G B KondoweD W Harron
Jun 1, 1988·Acta Physiologica Scandinavica·D L EckbergB G Wallin
Apr 1, 1986·The Journal of Clinical Investigation·T J EbertM Skelton
Apr 1, 1986·Clinical Science·T Bennett, S M Gardiner
Aug 1, 1986·The Journal of Physiology·F M AbboudB N Gupta
Sep 1, 1984·Journal of Cardiovascular Pharmacology·J F Liard

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