PMID: 11310503Apr 20, 2001Paper

Arginine-vasopressin neurons in the rat hypothalamus produce neurokinin B and co-express the tachykinin NK-3 receptor and angiotensin II type 1 receptor

Archives of Histology and Cytology
T HataeS Masuko

Abstract

Secretion of arginine-vasopressin (AVP) from the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei is induced by neurokinin B (NKB) and angiotensin. To characterize the mechanisms by which this occurs, we used immunohistochemical techniques to assess the ability of AVP-producing neurons to express NKB, NKB receptor (NK-3 receptor) and angiotensin II type 1 receptor (AT-1 receptor). Double fluorescence immunohistochemistry indicated that AVP-immunoreactive cell bodies in the PVN and SON, as well as their axon varicosities in the posterior pituitary, co-express NKB. Almost all AVP-neuron perikarya also expressed both the NK-3 receptor and AT-1 receptor. Thus, AVP-producing neurons in the PVN and SON, which are regulated by NKB, are themselves a source of NKB. Furthermore, the regulation of AVP release by these neurons by NKB and angiotensin II is mediated by the NK-3 receptor and the AT-1 receptor, respectively.

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Citations

Jan 31, 2004·European Journal of Pharmacology·Andrée LessardRéjean Couture
Jun 24, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Francis W FlynnZhaojie Zhang
Jul 25, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gwendolen E Haley, Francis W Flynn
Dec 24, 2003·Alcoholism, Clinical and Experimental Research·Craig J Slawecki, Jennifer Roth
Aug 31, 2010·Brain Research·Naomi E RancePenny A Dacks
Jul 21, 2015·Medical Hypotheses·Dori PitynskiDonal C Skinner
Dec 17, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gwendolen E Haley, Francis W Flynn
Apr 30, 2021·Science Advances·Laurence A LemaireMichael Levine

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