Arglabin: From isolation to antitumor evaluation

Chemico-biological Interactions
Shabir H LoneMohd A Khuroo

Abstract

Arglabin belongs to guaianolide class of sesquiterpene lactones, isolated from Artemisia species. The molecule bears a 5,7,5-tricyclic ring system having five contiguous stereo centers in which the two five membered rings are trans-annulated. Arglabin shows promising antitumor activity against different tumor cell lines. The antitumor activity of arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene, a process that is believed to play a pivotal role in 20-30% of all human tumors. It actually inhibits the incorporation of farnesyl pyrophosphate into human H-ras proteins by the enzyme farnesyl transferase (FTase). The present review is an attempt to summarize the chemistry and biology of this molecule since its isolation in 1982. It embodies the isolation, structure elucidation, stereo chemical description, structural classification, chemical synthesis, structural modifications and antitumor evaluation reported till date.

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Citations

Jun 24, 2017·Chemical Reviews·Bin MaoBen L Feringa
Jul 23, 2019·Organic & Biomolecular Chemistry·Alexey V Salin, Daut R Islamov
Sep 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pelin TastanJudit Hohmann
Jul 1, 2020·Natural Products and Bioprospecting·Shuang TangJi-Jun Chen
Oct 26, 2020·Organic & Biomolecular Chemistry·Marta RomaniszynŁukasz Albrecht
Aug 6, 2021·Planta medica·Uugangerel ErdenetsogtEnkhmaa Dagvadorj
Aug 28, 2020·Journal of Natural Products·Shuang TangJi-Jun Chen
Oct 23, 2020·The Journal of Organic Chemistry·Li-Hua SuJi-Jun Chen
Dec 9, 2020·Journal of Medicinal Chemistry·Yulin Ren, A Douglas Kinghorn
Oct 17, 2021·Molecular Biology Reports·Azadeh ManayiHamid Reza Khayat Kashani

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