Abstract
Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ≤2 mg/liter), 9 (1.3%) intermediate (MICs of 4 mg/liter), and 8 (1.1%) resistant (MICs of >32 mg/liter). Resistance was associated with rmtF-, rmtB-, or armA-encoded 16S rRNA methyltransferases in all except 1 isolate.
References
Mar 1, 1988·Antimicrobial Agents and Chemotherapy·W J Brown
Nov 15, 2013·Advances in Nutrition·Shelley McGuire
Dec 22, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Doaa GamalLuis Martínez-Martínez
May 22, 2016·Infectious Disease Clinics of North America·Yohei DoiYoshichika Arakawa
May 4, 2017·Antimicrobial Agents and Chemotherapy·Laura J RojasRobert A Bonomo
Dec 2, 2017·The Journal of Antimicrobial Chemotherapy·Stefano ManciniPatrice Nordmann
Feb 16, 2018·Clinical Microbiology Reviews·Jesús Rodríguez-BañoAlvaro Pascual
Mar 30, 2018·International Journal of Antimicrobial Agents·Emma TaylorKatie L Hopkins
Sep 17, 2018·The Journal of Antimicrobial Chemotherapy·Mariana CastanheiraRobert K Flamm
Oct 17, 2018·Antimicrobial Agents and Chemotherapy·Michael R JacobsRobert A Bonomo
Dec 5, 2018·Pharmacotherapy·Kristy M ShaeerJonathan C Cho
Jan 22, 2019·Diagnostic Microbiology and Infectious Disease·Mariana CastanheiraRodrigo E Mendes
Feb 17, 2019·BMC Infectious Diseases·Irene GalaniUNKNOWN Study Collaborators
Apr 11, 2019·Open Forum Infectious Diseases·Alisa W SerioKevin M Krause
Jul 23, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louis D Saravolatz, Gary E Stein
Nov 13, 2019·Antimicrobial Agents and Chemotherapy·Wim A FleischmannRobin Patel
Nov 22, 2019·Journal of Global Antimicrobial Resistance·Rujipas SirijatuphatVisanu Thamlikitkul
Citations
Jan 7, 2021·PloS One·Julalak C OntongSarunyou Chusri
Apr 4, 2021·Microorganisms·Corneliu Ovidiu VrancianuMariana Carmen Chifiriuc
Apr 4, 2021·Journal of Clinical Medicine·Erlangga YusufMireille van Westreenen
Apr 4, 2021·Journal of Chemotherapy·Marwa Mohamed Ezzat Abd-ElmonsefSara Youssef Maxwell