Argonaute proteins in cardiac tissue contribute to the heart injury during viral myocarditis

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Shougang SunBingren Gao

Abstract

MicroRNAs (miRNAs) are a group of short, noncoding, regulatory RNA molecules the dysregulation of which contributes to the pathogenesis of myocarditis. Argonaute proteins are essential components of miRNA-induced silencing complex and play important roles during miRNA biogenesis and function. However, the expression pattern of four AGO family members has not yet been detected in the coxsackievirus B3 (CVB3)-induced myocarditis tissue samples. In this study, we detected the expression of four AGOs in the CVB3-infected mouse heart tissues and found that AGO1 and AGO3 up-regulated significantly at 4 and 8h after CVB3 infection. Further in vitro research indicated that up-regulated AGO1 and AGO3 are related to the down-regulated TNFAIP3, which is a negative regulator of NF-κB pathway. Subsequently, we confirmed that TNFAIP3 is a direct target of miR-19a/b, and during CVB3 infection, the expression of miR-19a/b and miR-125a/b is not significantly changed. TNFAIP3 level is mainly reduced by up-regulated AGO1 and AGO3. This research sheds light on the relationship between overexpressed AGO proteins and CVB3-induced myocarditis, and this provides potential therapeutic target for viral myocarditis.

Citations

Aug 15, 2018·Critical Reviews in Microbiology·Ilka EngelmannDidier Hober
Aug 9, 2020·Journal of Gastroenterology and Hepatology·Seok-Jae KoJae-Woo Park
May 18, 2016·Wiley Interdisciplinary Reviews. RNA·Kotaro Nakanishi
Apr 10, 2020·Frontiers in Immunology·Jing Wang, Bo Han
Jan 27, 2017·Experimental and Therapeutic Medicine·Ling NiuXinjiang An

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