Dec 1, 1985

Argyrophilic cells in 202 human mucinous breast carcinomas. Relation to histopathologic and clinical factors

American Journal of Clinical Pathology
B B RasmussenK Hou-Jensen


Two hundred two human, mucinous breast carcinomas were investigated for the presence of argyrophilic granules, and these granules were found in 25% of the cases. The granules were located in the cytoplasm and were heterogeneously distributed within the tumors. Tumors with granules were otherwise morphologically indistinguishable from those tumors without granules. The recurrence-free survival was independent of the presence of granules, and no relation was found to other clinical or histopathologic factors. Tumors with granules were found to be estrogen-receptor positive, and they appear to have a slightly less aggressive growth pattern than tumors without granules, but the difference is far from being statistically significant. It is concluded that there is no convincing evidence that this group of primary breast carcinomas with argyrophilia originates from APUD cells.

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Mentioned in this Paper

Silver Nitrate, Silver (2+) Salt (2: 1)
Cell Growth Pattern
Carcinoid, Goblet Cell
Recurrent Malignant Neoplasm
Mucinous Adenocarcinoma
Recurrence (Disease Attribute)
Staining and Labeling
Mammary Neoplasms, Human

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