PMID: 9549729Apr 29, 1998Paper

Argyrophilic grains of Braak: occurrence in dendrites of neurons containing hyperphosphorylated tau protein

Neuropathology and Applied Neurobiology
M TolnayAlphonse Probst

Abstract

Braak's argyrophilic grains (ArGs) are spindle-shaped neuropil structures originally found in patients afflicted with adult onset dementia. We recently observed that tau protein is hyperphosphorylated in most nerve cells in areas rich in ArGs, suggesting that these grains may be a morphological expression of tau protein pathology in local neurons. The aim of this study was therefore to determine in three cases with ArGs whether grains are associated with individual neurons containing hyperphosphorylated tau. A combination of Gallyas silver staining and AT8 immunocytochemistry was used. AT8 is a monoclonal antibody that recognizes tau in a phosphorylation-dependent manner. Up to 80% of pyramidal cells of sector CA1 showed diffuse AT8 staining of their cell bodies and dendrites. Most grains were freely scattered throughout the neuropil. However, some were clearly located in side-branches of apical dendrites of AT8 immunoreactive pyramidal neurons. Dendritic branches often formed bush-like ramifications containing clusters of ArGs. Other dendrites consisted of a single stump containing one or two large grains at their tips. Spheroidal enlargements of dendritic branches, with a size corresponding to ArGs, were also found in Golgi C...Continue Reading

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Citations

Mar 10, 2006·Acta Neuropathologica·Zheng-Tong DingYoshio Hashizume
Dec 11, 2007·Acta Neuropathologica·Gabor G KovacsRohan de Silva
Oct 17, 2013·Journal of Neuropathology and Experimental Neurology·Robert SimanYina Dong
Oct 24, 1998·Experimental Neurology·H Braak, E Braak
Jun 11, 2016·Journal of Neuropathology and Experimental Neurology·Roberta Diehl RodriguezLea Tenenholz Grinberg
Feb 1, 2008·Brain : a Journal of Neurology·Isidro FerrerFred W van Leeuwen
Jan 12, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Markus Tolnay, Florence Clavaguera
Dec 18, 2013·Journal of Neuropathology and Experimental Neurology·Shinsui TatsumiMari Yoshida
Jul 27, 1999·Neuropathology and Applied Neurobiology·M Tolnay, A Probst
Jul 27, 1999·Pathology International·T KawashimaT Iwaki
Dec 22, 2019·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Renpei Sengoku
Apr 18, 1998·Brain Pathology·K A Jellinger
Jul 27, 2000·Annals of the New York Academy of Sciences·H BraakE Braak
Apr 5, 2005·Journal of Neuropathology and Experimental Neurology·Yasuhiro FujinoDennis W Dickson
Jun 20, 2002·Journal of Neuropathology and Experimental Neurology·Takashi TogoDennis W Dickson
Jan 1, 2015·Dementia & Neuropsychologia·Roberta Diehl Rodriguez, Lea Tenenholz Grinberg
Apr 30, 2017·Journal of Alzheimer's Disease : JAD·Naoki KasahataKatsuiku Hirokawa
Jan 1, 2009·Dementia & Neuropsychologia·Lea T Grinberg, Helmut Heinsen

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