PMID: 9444364Jan 28, 1998Paper

Argyrophilic inclusions distinct from Alzheimer neurofibrillary changes in one case of dialysis-associated encephalopathy

Acta Neuropathologica
Erich Reusche

Abstract

A 72-year-old female demonstrated neurofibrillary changes of Alzheimer's disease (AD) as well as morphological features of dialysis-associated encephalopathy (DAE). This unique autopsy case was selected from a group of 127 patients with a history of long-term hemodialysis. Silver-stained paraffin sections revealed hall-marks of DAE with characteristic fine-granular aluminium-containing inclusions in the cytoplasm of plexus epithelia, cortical glia and neurons. Additionally, neurofibrillary tangles (NFT) and neuropil threads of the AD-type were demonstrated, consisting of paired helical filaments. No beta/A4 amyloid deposits were present. AD changes have been interpreted as age-related phenomena. Concerning the role of aluminium (Al) in AD, our morphological findings indicate that Al-induced DAE changes develop via different pathogenetic pathways compared to AD. Transferrin receptors stained positively in choroid plexus and neurons, in glial cells of the gray and white matter, in cerebellar (DAE-negative) Purkinje and granule cells as well as in AD-type NFT (and additionally in NFT of AD controls). This points to the ubiquitous distribution of transferrin receptors rather than to specific patterns in DAE and/or AD. Laser micropr...Continue Reading

Citations

Nov 16, 2001·Journal of Inorganic Biochemistry·M SargaziA Shenkin
Nov 6, 2002·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Teruo ShirabeMasako Uchida
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
May 9, 2014·Journal of Occupational and Environmental Medicine·Theodore I Lidsky
Jun 23, 2009·Trends in Pharmacological Sciences·Paolo ZattaStefano L Sensi
Apr 20, 2012·Critical Reviews in Toxicology·Calvin C WillhiteClifton J McLellan
Aug 15, 2000·American Journal of Clinical Pathology·L D BoucherK R Geisinger
Feb 3, 2000·Journal of Clinical Microbiology·J GieffersM Maass

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