Argyrophilic nucleolar organizer region counts in squamous cell carcinomas of the head and neck after irradiation and chemotherapy

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
D S HammerU Pfeifer

Abstract

After irradiation or chemotherapy of tumors of the head and neck, histological alterations might be difficult to assess. In 30 cases of squamous cell carcinomas of the pharynx, changes in argyrophilic nucleolar organizer region (AgNOR) counts were investigated after therapy. After treatment a significant decrease of AgNOR counts was detected (P < 0.001). No significant differences could be found between groups treated with radiotherapy, chemotherapy or a combination of radiotherapy and chemotherapy. These findings suggest that AgNOR counts might be useful to assess cytotoxic effects on a subcellular level.

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