PMID: 7520349Sep 1, 1994Paper

Argyrophilic nucleolar organizer region counts predict survival in thymoma

Cancer
A PichG Palestro

Abstract

The prognosis of thymoma is related mainly to the tumor stage. The prognostic value of argyrophilic nucleolar organizer regions (AgNORs) has been demonstrated in several human neoplasias. Ninety primary thymomas were investigated retrospectively to assess whether AgNOR analysis could offer additional prognostic information. Sections from surgically resected thymomas, routinely fixed in formol and embedded in paraffin, were stained with the argyrophilic method of Ploton. The mean number of AgNORs in the nuclei of 100 tumor cells (AgNOR counts) was calculated for each case. The association between AgNOR counts and survival was assessed by means of uni- and multivariate survival analyses. On univariate analysis, AgNOR counts were associated significantly with 5- and 10-year survival rates (95% and 90%, respectively, for thymomas with 5.58 or fewer AgNORs per cell, but only 55% and 44%, respectively, for tumors with more than 5.58 AgNORs per cell; P < 0.0001). Histologic subtypes of the American classification (P = 0.0006) and clinical stage (P < 0.0001) also were correlated with prognosis. The multivariate survival analysis showed that AgNOR counts (P = 0.001), clinical stage (P < 0.001), and age (P = 0.011) were independent progn...Continue Reading

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Citations

Jun 21, 1996·International Journal of Cancer. Journal International Du Cancer·A PichG Palestro
Dec 10, 1999·Micron : the International Research and Review Journal for Microscopy·A PichE Margaria
Jan 22, 2002·The American Journal of Dermatopathology·G TuccariD Batolo
Sep 10, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yukiko HiroseAkira Tangoku
Apr 1, 1996·Japanese Journal of Cancer Research : Gann·K MaruyamaH Sugimura
Aug 5, 2014·British Poultry Science·N Gündüz, Y Oznurlu

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