ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk.

Translational Psychiatry
Mariko SekiguchiNorio Ozaki

Abstract

Schizophrenia (SCZ) is known to be a heritable disorder; however, its multifactorial nature has significantly hampered attempts to establish its pathogenesis. Therefore, in this study, we performed genome-wide copy-number variation (CNV) analysis of 2940 patients with SCZ and 2402 control subjects and identified a statistically significant association between SCZ and exonic CNVs in the ARHGAP10 gene. ARHGAP10 encodes a member of the RhoGAP superfamily of proteins that is involved in small GTPase signaling. This signaling pathway is one of the SCZ-associated pathways and may contribute to neural development and function. However, the ARHGAP10 gene is often confused with ARHGAP21, thus, the significance of ARHGAP10 in the molecular pathology of SCZ, including the expression profile of the ARHGAP10 protein, remains poorly understood. To address this issue, we focused on one patient identified to have both an exonic deletion and a missense variant (p.S490P) in ARHGAP10. The missense variant was found to be located in the RhoGAP domain and was determined to be relevant to the association between ARHGAP10 and the active form of RhoA. We evaluated ARHGAP10 protein expression in the brains of reporter mice and generated a mouse model t...Continue Reading

References

Mar 21, 1998·Schizophrenia Bulletin·H HäfnerA Stein
Jul 11, 2000·Acta Psychiatrica Scandinavica. Supplementum·A Leung, P Chue
Aug 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Volker EndrisGudrun A Rappold
Dec 10, 2003·Archives of General Psychiatry·Patrick F SullivanMichael C Neale
Jan 3, 2004·Nature Neuroscience·Sonia BishopAndrew D Lawrence
Jan 5, 2005·Genes & Development·Eve-Ellen GovekLinda Van Aelst
May 10, 2005·Bioinformatics·Carles Ferrer-CostaModesto Orozco
Jan 16, 2007·Biology of the Cell·Joseph Tcherkezian, Nathalie Lamarche-Vane
Feb 22, 2007·Nature Reviews. Neuroscience·Nariko Arimura, Kozo Kaibuchi
Apr 25, 2007·Psychological Medicine·Niels BergemannChristoph Mundt
May 31, 2008·Nature Genetics·Bin XuMaria Karayiorgou
Aug 23, 2008·Nature Reviews. Molecular Cell Biology·Sarah J Heasman, Anne J Ridley
Dec 24, 2008·The Journal of Biological Chemistry·Kazutaka MoriKozo Kaibuchi
Apr 7, 2009·American Journal of Human Genetics·Helen V FirthNigel P Carter
Jan 15, 2010·Nucleic Acids Research·F LeprêtreM Figeac
Feb 26, 2010·Cold Spring Harbor Perspectives in Biology·Alan Hall, Giovanna Lalli
Apr 1, 2010·Nature Methods·Ivan A AdzhubeiShamil R Sunyaev
May 14, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cecilia CondeAlfredo Cáceres
Aug 31, 2010·Cytoskeleton·Mutsuki AmanoKozo Kaibuchi
May 3, 2011·Progress in Neurobiology·Kimberley F ToliasKyongmi Um
Oct 3, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Baptiste RiffaultChristophe Porcher
Oct 24, 2014·Frontiers in Cellular Neuroscience·Trisha R Stankiewicz, Daniel A Linseman
May 1, 2015·Genome Biology·Tomomi AidaKohichi Tanaka
Nov 11, 2015·Proceedings of the National Academy of Sciences of the United States of America·David S WheelerSusan G Amara
Apr 19, 2016·Journal of Neurodevelopmental Disorders·Madita SchumannHeiko Reutter
Jun 1, 2016·Molecular Psychiatry·I KushimaN Ozaki
Jun 16, 2016·Nature Reviews. Molecular Cell Biology·Richard G Hodge, Anne J Ridley
Nov 22, 2016·Nature Genetics·Christian R MarshallUNKNOWN CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium
Jun 28, 2017·Nature Communications·Tetsuya TakanoKozo Kaibuchi
May 17, 2018·Human Molecular Genetics·Jacob A S VorstmanUNKNOWN GROUP investigators
Jul 20, 2018·Translational Psychiatry·Yuko AriokaNorio Ozaki

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
nucleotide exchange
GTPases
PCR
genotyping
Assay
immunoprecipitation
pull-down

Software Mentioned

Ensembl
PolyPhen
CopyCaller
PolyPhen2
IncuCyte
IncuCyte Zoom
Mutation Surveyor DNA Analysis Software
FastPCR
PrimerDigital
NeuroTracker

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.