ARID1A Deficiency May Predict Response to Immune Checkpoint Blockade

Cancer Discovery

Abstract

ARID1A deficiency impairs mismatch repair to increase tumor mutation load and promote tumor progression.

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.