journal cover

ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

Nature Genetics

Jan 9, 2020

Sankari NagarajanJason S Carroll

Abstract

Using genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screens to understand endocrine drug resistance, we discovered ARID1A and other SWI/SNF complex components as the factors most critically required for response to two classes of estrogen receptor-alpha ...read more

Mentioned in this Paper

Inhibitors
Genome-Wide Association Study
Breast Cancer Cell
Repressor Proteins
ARID1A protein, human
BDF1 protein, S cerevisiae
Chromatin
Response to Treatment
Gene Deletion
BRD4 protein, human
62
1
Paper Details
References
  • References51
  • Citations
12345...
  • References51
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Hormone-Related Cancers

This feed focuses on hormone-related cancers including cancer of the breast, endometrium, ovary, prostate, testis, thyroid, and bone, all of which share unique mechanisms of carcinogenesis. Here is the latest research.

Chromatin Remodeling

Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.

Cis & Trans Regulatory Elements

Cis-regulatory elements are regions DNA that regulate the transcription of neighbouring genes. Trans-regulatory elements are genomic loci that regulate the expression of distant genes. Here is the latest research on CREs and TREs.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Chromatin Remodeling (Keystone)

Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying this process.

Chromatin Remodelling

Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.

Cis- & Trans-Regulatory Elements

Cis-regulatory elements are DNA regions that regulate the transcription of neighbouring genes. Trans-regulatory elements are genomic loci that regulate the expression of distant genes by encoding transcription factors. Here is the latest research on CREs and TREs.

Enhancer Decommissioning (Keystone)

Enhancers are regions of DNA that can be bound by proteins to increase the likelihood of transcription. Follow this feed to discover research relate to enhancer decommissioning.

Related Papers

© 2020 Meta ULC. All rights reserved

ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

Nature Genetics

Jan 9, 2020

Sankari NagarajanJason S Carroll

PMID: 31913353

DOI: 10.1038/s41588-019-0541-5

Abstract

Using genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screens to understand endocrine drug resistance, we discovered ARID1A and other SWI/SNF complex components as the factors most critically required for response to two classes of estrogen receptor-alpha ...read more

Mentioned in this Paper

Inhibitors
Genome-Wide Association Study
Breast Cancer Cell
Repressor Proteins
ARID1A protein, human
BDF1 protein, S cerevisiae
Chromatin
Response to Treatment
Gene Deletion
BRD4 protein, human
62
1

Similar Papers Found In These Feeds

Hormone-Related Cancers

This feed focuses on hormone-related cancers including cancer of the breast, endometrium, ovary, prostate, testis, thyroid, and bone, all of which share unique mechanisms of carcinogenesis. Here is the latest research.

Chromatin Remodeling

Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying chromatin remodeling.

Related Papers

Journal of Arthropod-borne Diseases

Curbing Malaria: A New Hope through Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) Technology

Journal of Arthropod-borne DiseasesJanuary 26, 2018
Manjit Panigrahi, Ansuman Panigrahi
Paper Details
References
  • References51
  • Citations
12345...
  • References51
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
/papers/arid1a-influences-hdac1brd4-activity-intrinsic/31913353