Aripiprazole long-acting injectable formulations for schizophrenia: aripiprazole monohydrate and aripiprazole lauroxil

Expert Review of Clinical Pharmacology
Leslie Citrome

Abstract

Aripiprazole monohydrate (AM) and aripiprazole lauroxil (AL) are two different long-acting injectable formulations of aripiprazole. AM 400 mg administered once monthly demonstrated efficacy in an acute, double-blind, placebo-controlled, randomized clinical trial, as well as in a double-blind, placebo-controlled, randomized-withdrawal maintenance study, and in two non-inferiority maintenance studies. AL is a prodrug of aripiprazole and available in 441 mg, 662 mg or 882 mg strengths. AL 441 mg and 882 mg administered once monthly demonstrated efficacy in an acute, double-blind, placebo-controlled, randomized clinical trial. The pharmacokinetic profile of AL also led to approval of dosing intervals of every 6 weeks for the 882 mg dose. The overall tolerability profiles of both products are consistent with what is known about oral aripiprazole.

References

Nov 28, 2017·Drugs·James E Frampton
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Citations

May 16, 2008·Acta Psychiatrica Scandinavica·Leslie Citrome
Jul 9, 2008·Drug Development and Industrial Pharmacy·Tushar Nahata, Tulsi Ram Saini
Jan 26, 2011·Schizophrenia Research·Maria Rosaria A MuscatelloRocco A Zoccali
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May 17, 2011·Patient Preference and Adherence·François CaroliAntonio Delgado
Aug 1, 2013·Expert Review of Neurotherapeutics·Leslie Citrome
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Related Concepts

Study
Antipsychotic Effect
Injection Product
Periodontal Attachment Loss
Schizophrenia
Clinical Trials, Randomized
Aripiprazole
Controlled Clinical Trials, Randomized
OPC 14597
Nonclinical Randomization

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