Aripiprazole/Methylphenidate Combination in Children and Adolescents with Disruptive Mood Dysregulation Disorder and Attention-Deficit/Hyperactivity Disorder: An Open-Label Study

Journal of Child and Adolescent Psychopharmacology
Pei-Yin PanChin-Bin Yeh

Abstract

Disruptive mood dysregulation disorder (DMDD) is characterized by nonepisodic irritability and has a high rate of comorbidity with attention-deficit/hyperactivity disorder (ADHD). This is the first study to explore the effects of aripiprazole combined with methylphenidate on clinical symptoms and cognitive functions in patients with DMDD and ADHD. Patients with DMDD and ADHD (the DMDD-ADHD Group, n = 24; aged 7-17 years) completed a 6-week, open-label trial of aripiprazole and methylphenidate. The pre- and posttreatment outcome measures included the parent-rated Swanson, Nolan, and Pelham Scale-version IV, Child Behavior Checklist, and self-reported Beck Youth Inventories-II, as well as a neuropsychological battery composed of the Children's Color Trail Test and Conner's Continuous Performance Test. The comparison group consisting of patients with ADHD (the ADHD Group, n = 27) was recruited to investigate the differences in clinical and neuropsychological profiles between the two groups at baseline. The DMDD-ADHD Group showed worse irritability, disruptive behaviors, anxious/depressed symptoms, and social problems relative to the ADHD Group at baseline assessments. The combination treatment significantly improved irritability, ...Continue Reading

References

Aug 3, 2000·Journal of Clinical and Experimental Neuropsychology·K Arbuthnott, J Frank
Sep 15, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·H J YangW T Soong
Oct 24, 2006·Biological Psychiatry·Melissa A BrotmanEllen Leibenluft
Feb 21, 2008·International Journal of Methods in Psychiatric Research·Susan Shur-Fen GauChang-Ling Tu
Feb 24, 2009·Journal of Child and Adolescent Psychopharmacology·Daniel P DicksteinEllen Leibenluft
Jul 3, 2009·The American Journal of Psychiatry·Argyris StringarisEllen Leibenluft
Nov 4, 2009·The American Journal of Psychiatry·Joseph C BladerVivian Kafantaris
Jan 13, 2010·Journal of Affective Disorders·Timo D VloetThomas Günther
Sep 30, 2010·Journal of Attention Disorders·Michael J ManosPeter S Jensen
Jun 15, 2011·Journal of Child and Adolescent Psychopharmacology·Fernanda Valle KriegerLuis Augusto Rohde
Dec 24, 2011·The American Journal of Psychiatry·Argyris StringarisThalia C Eley
May 30, 2012·Pediatrics·Nancy Scotto RosatoUNKNOWN Treatment of Maladaptive Aggressive in Youth Steering Committee
Feb 5, 2013·The American Journal of Psychiatry·William E CopelandHelen Egger
Dec 18, 2013·Journal of the American Academy of Child and Adolescent Psychiatry·Michael G AmanRobert L Findling
Jan 22, 2014·Psychological Medicine·L R DoughertyD N Klein
Feb 1, 2014·The American Journal of Psychiatry·Philip ShawEllen Leibenluft
Dec 17, 2014·Depression and Anxiety·Christen M DeveneyEllen Leibenluft
Dec 20, 2014·Journal of the American Academy of Child and Adolescent Psychiatry·Lorena Fernández de la CruzArgyris Stringaris
Jul 2, 2015·JAMA Psychiatry·Christoph U Correll, Joseph C Blader
Sep 21, 2015·Lancet·Anita Thapar, Miriam Cooper
Feb 24, 2016·Journal of the American Academy of Child and Adolescent Psychiatry·James G WaxmonskyWilliam E Pelham
Jun 28, 2016·Journal of the American Academy of Child and Adolescent Psychiatry·Pablo Vidal-RibasArgyris Stringaris
Oct 4, 2016·Journal of Clinical and Experimental Neuropsychology·Barbara M RufMichael C Stevens
Apr 24, 2017·Journal of the American Academy of Child and Adolescent Psychiatry·David PagliaccioEllen Leibenluft
Nov 7, 2017·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Michelle A Pievsky, Robert E McGrath
Nov 8, 2017·Current Psychiatry Reports·Baptiste PignonAntoine Pelissolo

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Citations

Jun 25, 2019·International Journal of Psychiatry in Clinical Practice·Elisa D'AgatiLuigi Mazzone
Nov 30, 2019·International Review of Psychiatry·Brian HendricksonLeslie Miller
Jul 28, 2019·JAMA Network Open·Ryan S SultanMark Olfson
Sep 8, 2020·Expert Opinion on Drug Safety·Felice IasevoliAndrea de Bartolomeis
Sep 16, 2020·Journal of Child and Adolescent Psychopharmacology·Nicolas CoustalsDavid Cohen
Oct 22, 2020·International Clinical Psychopharmacology·Pavel Golubchik, Abraham Weizman
Feb 19, 2021·Journal of Child and Adolescent Psychopharmacology·Megan BakerGabrielle A Carlson
Jun 1, 2021·Child and Adolescent Psychiatric Clinics of North America·Carrie VaudreuilJanet Wozniak
Jun 1, 2021·Child and Adolescent Psychiatric Clinics of North America·Manpreet K SinghDavid J Miklowitz
Jul 8, 2021·European Child & Adolescent Psychiatry·Ines Mürner-LavanchyJulian Koenig

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NCT03358277

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SPSS

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