Arisugacins, selective acetylcholinesterase inhibitors of microbial origin

Pharmacology & Therapeutics
K OtoguroSatoshi Omura

Abstract

Synthetic inhibitors of acetylcholinesterase (AChE) recently have attracted particular attention for treatment of Alzheimer's disease. By systematic screening of microbial metabolites, we were able to discover the new AChE inhibitors, named arisugacins A and B, from the culture broth of Penicillium sp. FO-4259. The structures of arisugacins are members of the meroterpenoid compounds. Arisugacin A is a potent and highly selective inhibitor of AChE but does not inhibit butyrylcholinesterase in vitro. Arisugacin A is a good candidate as an excellent potential drug for treatment of Alzheimer's disease. Also reviewed is the current status of development of antidementia drugs.

References

Mar 1, 1979·Applied and Environmental Microbiology·K H LingF T Peng
Oct 1, 1979·The American Journal of Psychiatry·R C MohsB S Kopell
Dec 1, 1991·Pharmacology & Therapeutics·J A Court, E K Perry
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·N W KowallB A Yankner
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S A FrautschyG M Cole
Jun 1, 1990·Japanese Journal of Pharmacology·K NatoriJ Katsube
Nov 13, 1986·The New England Journal of Medicine·W K SummersA Kling
Oct 1, 1986·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·H Kuribara
May 1, 1974·The Journal of Antibiotics·K OgataY Tani
Dec 1, 1984·Journal of Neurochemistry·A J CrossJ A Corsellis
Mar 11, 1995·Lancet·K L Davis, P Powchik
Jun 1, 1995·Journal of Natural Products·F C Peng
May 13, 1995·Lancet·P Chrispin
Oct 21, 1994·Journal of Molecular Biology·M Y MizutaniA Itai
Apr 2, 1993·Neuroscience Letters·V L ArvanovM C Tsai
Apr 2, 1994·BMJ : British Medical Journal·N MaltbyW S Brooks
Aug 1, 1993·The Journal of Antibiotics·T KurokawaN Harada

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Citations

Jul 13, 2000·Bioorganic & Medicinal Chemistry Letters·R ObataS Omura
Dec 24, 2013·Chemical Reviews·Francisco A MacíasJuan C G Galindo
Jul 13, 2005·Natural Product Reports·Gerard P McGlacken, Ian J S Fairlamb
Mar 31, 2006·Natural Product Reports·Peter J HoughtonMelanie-Jayne Howes
Nov 19, 2013·The Journal of Pharmacy and Pharmacology·Brígida R PinhoPaula B Andrade
Aug 27, 2015·AMB Express·John Selesteen Charles Adlin JeniferThavasimuthu Citarasu
Mar 30, 2019·Natural Product Reports·Lindon W K MoodieJohan Svenson
Nov 12, 2010·Journal of Enzyme Inhibition and Medicinal Chemistry·Jaroslav SebestíkM Amélia Santos
Oct 28, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Petr ZelíkJirí Kopecký
Aug 18, 2020·AMB Express·Thomas IsbrandtThomas O Larsen
Dec 29, 2006·Chemistry & Biodiversity·Xiangrui JiangYu Zhao
Jul 25, 2019·Archives of Microbiology·Fatima MucceeNaheed Riaz
Jan 26, 2008·Accounts of Chemical Research·Toshiaki SunazukaSatoshi Omura
Dec 15, 2005·Chemical Reviews·Toshiaki Sunazuka, Satoshi Omura

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