ARLTS1 variants and melanoma risk

International Journal of Cancer. Journal International Du Cancer
Bernd FrankBarbara Burwinkel

Abstract

Variants in the tumor suppressor gene ARLTS1 (ADP-ribosylation factor-like tumor-suppressor gene 1) have been shown to influence familial cancer risk. Both Cys148Arg and Trp149Stop were associated with an increased risk of familial or high-risk familial breast cancer, respectively. We studied the impact of these gene variants on melanoma risk, investigating 351 melanoma patients and 804 control subjects. While ARLTS1 Trp149Stop did not influence melanoma risk (OR = 0.83, 95% CI = 0.37-1.88, p = 0.65), Cys148Arg revealed a statistically significant association with an increased risk for heterozygous carriers (OR = 1.43, 95% CI = 1.05-1.95, p = 0.02). An additional risk enhancement, though statistically non-significant, was observed in individuals with multiple melanomas (OR = 2.33, 95% CI = 0.87-6.26, p = 0.08).

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Citations

Mar 14, 2008·European Journal of Human Genetics : EJHG·Sanna SiltanenPia Vahteristo
Jan 5, 2008·Carcinogenesis·Rongxi YangBarbara Burwinkel
Jan 1, 2007·Hereditary Cancer in Clinical Practice·Xuchen LiRajiv Kumar
Aug 14, 2013·PloS One·Sanna SiltanenJohanna Schleutker
Jan 15, 2016·Journal of Human Genetics·Mitchell J MachielaStephen J Chanock
Apr 1, 2008·Cancer Letters·Sai YendamuriGeorge A Calin
Feb 3, 2009·Cancer Science·Katia SampieriFrancesca Ariani
Apr 24, 2007·Carcinogenesis·Sergi Castellví-BelUNKNOWN Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
May 20, 2020·Frontiers in Cell and Developmental Biology·Cristina CasalouDuarte C Barral
Jun 21, 2017·Hereditary Cancer in Clinical Practice·Yan JiangHui-Yi Lv
Apr 2, 2010·Molecular Biology Reports·Elif AkisikNejat Dalay
Oct 20, 2020·Frontiers in Cell and Developmental Biology·Cheila BritoMarta Pojo
Nov 3, 2006·Cancer Research·Fabio PetroccaCarlo M Croce
May 8, 2007·Cancer Research·Bartlomiej MasojcLeszek Rychlewski
Aug 19, 2007·Cancer Research·Sai YendamuriGeorge A Calin

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