Armadillo/beta-catenin-dependent Wnt signalling is required for the polarisation of epidermal cells during dorsal closure in Drosophila

Development
Véronique Morel, Alfonso Martinez Arias

Abstract

At the end of germband retraction, the dorsal epidermis of the Drosophila embryo exhibits a discontinuity that is covered by the amnioserosa. The process of dorsal closure (DC) involves a coordinated set of cell-shape changes within the epidermis and the amnioserosa that result in epidermal continuity. Polarisation of the dorsal-most epidermal (DME) cells in the plane of the epithelium is an important aspect of DC. The DME cells of embryos mutant for wingless or dishevelled exhibit polarisation defects and fail to close properly. We have investigated the role of the Wingless signalling pathway in the polarisation of the DME cells and DC. We find that the beta-catenin-dependent Wingless signalling pathway is required for polarisation of the DME cells. We further show that although the DME cells are polarised in the plane of the epithelium and present polarised localisation of proteins associated with the process of planar cell polarity (PCP) in the wing, e.g. Flamingo, PCP Wingless signalling is not involved in DC.

References

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Apr 18, 2000·The Journal of Cell Biology·D P KiehartR A Montague
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Apr 3, 2003·Nature Reviews. Molecular Cell Biology·Alfonso Martinez Arias
Sep 12, 2003·Developmental Cell·Michael T VeemanRandall T Moon
Nov 19, 2003·Mechanisms of Development·Suzanne Eaton

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Citations

Apr 13, 2013·PloS One·Weiping ShenNicholas Harden
Dec 22, 2005·Nature Reviews. Genetics·Alfonso Martinez Arias, Penelope Hayward
Apr 1, 2008·Trends in Genetics : TIG·Sophie QuintinMichel Labouesse
Sep 29, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yaiza Belacortu, Nuria Paricio
Oct 18, 2008·Current Biology : CB·Renata BolognesiSusan J Brown
Jul 21, 2010·Developmental Cell·Mingfu WuMichelle D Tallquist
Sep 11, 2007·Developmental Biology·Ryan W Fiehler, Tanya Wolff
Jun 21, 2020·Nature Communications·Kun-Yang LinHwei-Jan Hsu
Oct 11, 2017·Annual Review of Cell and Developmental Biology·Daniel P KiehartGlenn S Edwards

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