Aromatase, 5-alpha-reductase, and androgen receptor levels in the fetal monkey brain during early development

Neuroendocrinology
S A Sholl, K L Kim

Abstract

Aromatase, 5 alpha-reductase and cytosolic androgen receptor levels were measured in the medial basal hypothalamus (MHB), amygdala (AMG), cerebellum and cerebral cortex of male and female fetal rhesus monkeys on day 70 of gestation. Higher aromatase activities were noted in the MBH and AMG of male than female fetuses. In contrast, no sex differences were found for 5 alpha-reductase and androgen receptor levels. These data suggest that at this early stage of development, differentiation of the MBH and AMG of the male fetus may be more susceptible to androgen modification, by way of aromatization to estrogens, than corresponding areas in the female fetus. Moreover, based upon a comparison of the current data to that published previously for later stages of development, it is suggested that the sex differences in aromatase activity are not the result of androgen stimulation.

Citations

Dec 1, 1991·Molecular and Cellular Endocrinology·N J Busbridge, A B Grossman
Oct 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·N Yamada-MouriJ Kato
Aug 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·P Negri-CesiF Celotti
Oct 19, 2002·Progress in Neurobiology·Roberto C MelcangiMariarita Galbiati
Mar 30, 2005·Anatomical Science International·Yoshihiro Tsuruo
Jun 3, 2008·Neuroscience Letters·Charles E Wood, Maureen Keller-Wood
Oct 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Evangelia KallivretakiHelmut Segner

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