PMID: 8443685Feb 1, 1993Paper

Aromatase activity in human osteoblast-like osteosarcoma cell

Calcified Tissue International
S TanakaH Nawata

Abstract

Aromatase activity was studied in cultured human osteosarcoma cell (HOS). HOS was incubated from 12 to 72 hours with 10(-10) M-10(-5) M dexamethasone. Aromatase activity was determined by measuring [3H]H2O released upon the conversion of [1 beta-3H]androstenedione to estrone. HOS showed aromatase activity, and apparent km for [1 beta-3H]androstenedione was 4.46 +/- 0.98 nm (mean +/- SD). The aromatase activity was significantly increased by 10(-9) M-10(-5) M dexamethasone in a dose-dependent manner. Dexamethasone increased Vmax of aromatase activity but did not change its km value. These results suggest that osteoblastic cells have aromatase activity which is regulated by glucocorticoid, and directly convert androgen to estrogen in itself.

References

Aug 1, 1979·Endocrinology·L E Valladares, A H Payne
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M J OurslerT C Spelsberg
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R PacificiL V Avioli
Aug 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M PenslerC B Langman
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R PacificiW A Peck
Nov 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J R BuchananL M Demers
Apr 1, 1985·The Journal of Clinical Endocrinology and Metabolism·B E NordinS Deam
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M ErnstE R Froesch
Jan 1, 1985·The Journal of Clinical Endocrinology and Metabolism·W H ClelandE R Simpson
Feb 1, 1973·The Journal of Clinical Endocrinology and Metabolism·J M GrodinP C MacDonald
Aug 1, 1981·The Journal of Clinical Endocrinology and Metabolism·G E AckermanE R Simpson

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Citations

Feb 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·P V BodineT C Spelsberg
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·H NawataM Haji
Jan 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·R De CosterJ Bruynseels
Nov 14, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Pablo J Enriori, Carlos L Enriori
Aug 27, 1998·The Journal of Steroid Biochemistry and Molecular Biology·G FiorelliM L Brandi
Apr 24, 1999·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·R HirunumaF Ambe
Jun 1, 1995·The Journal of Clinical Investigation·T BellidoS C Manolagas
Oct 23, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y DongP P Tamburini
Nov 25, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E DamienL E Lanyon
Apr 28, 2009·Critical Reviews in Eukaryotic Gene Expression·Clifford J RosenAna Maria Pino
Feb 13, 2001·Biochemical and Biophysical Research Communications·C MiyauraA Ito
Jul 21, 2011·Journal of Osteoporosis·Daniela MerlottiRanuccio Nuti
Sep 1, 1996·Calcified Tissue International·D VanderschuerenR Bouillon
Sep 26, 2015·International Journal of Molecular Sciences·Daniel WysokinskiElzbieta Pawlowska
Oct 2, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yasuhiro MikiHironobu Sasano
Jun 5, 2007·Endocrinology and Metabolism Clinics of North America·Luigi Gennari, John P Bilezikian
Jun 19, 2012·Journal of Internal Medicine·M KawaiC J Rosen
Apr 11, 2001·Obstetrics and Gynecology Clinics of North America·J V ZborowskiJ A Cauley
Oct 27, 2011·BMB Reports·Jae-Hwan Jeong, Je-Yong Choi
Jul 31, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Nadia Mohd EffendyAhmad Nazrun Shuid
Jun 9, 2004·Steroids·Norio KagawaShiro Yoshioka
Feb 26, 2004·Journal of Dental Research·T FujitaK Tanne
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·R MarcusC A Quigley
Mar 1, 2006·Expert Review of Endocrinology & Metabolism·Luigi GennariJohn P Bilezikian
Jun 8, 2004·Endocrine Reviews·Dirk VanderschuerenClaes Ohlsson
May 1, 1995·Calcified Tissue International·D Vanderschueren, R Bouillon
Jun 23, 2000·Andrologia·D Vanderschueren, L Vandenput
May 10, 2000·Journal of Endocrinological Investigation·A Gambineri, R Pasquali

❮ Previous
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