Aromatase expression in endometriotic tissues and cell cultures of patients with endometriosis

Molecular Human Reproduction
Irene VelascoPedro Acién

Abstract

Cytochrome P-450 aromatase is responsible for catalysing the conversion of androstendione into estrone, so its expression in endometriotic tissue could contribute to the development of endometriosis. The aims of this study were, on the one hand, to determine the presence of aromatase in eutopic and ectopic endometrium, healthy peritoneum, myometrium and leiomyomas from patients with (n = 61) and without endometriosis (n = 12) and, on the other hand, to determine the effect of peritoneal fluid (PF), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNFalpha) on aromatase activity from endometriotic stromal cells and subcutaneous adipocytes. After immunohistochemical analysis, aromatase expression was detected in the endometriotic tissue of 61% of patients, whereas the rest of the tissues, as well as those from disease-free women, were negative. Cell cultures were made to determine aromatase activity in endometriotic stromal cells and adipocytes. The addition of PF, TNFalpha and especially IL-6 (P < 0.05) stimulated the basal enzymatic activity observed in both cell types. Our findings confirm the presence of aromatase in endometriosis and probably the existence of a local estrogen production that may be stimulated by some f...Continue Reading

Citations

Jul 25, 2012·Archives of Gynecology and Obstetrics·Matteo MorottiSimone Ferrero
Jan 13, 2009·Human Reproduction·Lu Vinh Phuc TranIan S Fraser
Jun 6, 2009·Human Reproduction·S ColetteJ Donnez
Jun 16, 2011·Human Reproduction Update·K E MayC M Becker
Jun 5, 2007·Current Opinion in Oncology·Olaf Reich, Sigrid Regauer
Dec 18, 2008·Reproductive Sciences·Tannaz ToloubeydokhtiNasser Chegini
Jun 23, 2011·Reproductive Biology and Endocrinology : RB&E·Warren B Nothnick
Jun 23, 2011·Reproductive Biology and Endocrinology : RB&E·Simone FerreroValentino Remorgida
Aug 29, 2014·BioMed Research International·Gabriella ZitoGiuseppe Ricci
Apr 3, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hugo MaiaJorge Valente Filho
Mar 13, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hugo MaiaCélia Athayde
Jun 18, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jozef HatokPeter Racay
May 10, 2012·Expert Opinion on Investigational Drugs·Ana Luiza L RochaFelice Petraglia
May 3, 2011·Expert Opinion on Investigational Drugs·Sébastien Colette, Jacques Donnez
Jan 19, 2016·Molecular and Cellular Endocrinology·Yanchun Liang, Shuzhong Yao
Aug 31, 2011·Molecular and Cellular Endocrinology·Kaisa HuhtinenMatti Poutanen
Jul 19, 2011·Fertility and Sterility·Amelie FassbenderThomas D'Hooghe
Dec 31, 2015·Human Reproduction Update·Roberto MaggiPatrizia Limonta
Jun 29, 2010·Fertility and Sterility·Subrata Lall SealArup Kr Majhi
Mar 6, 2007·Fertility and Sterility·Pedro AciénMonserrat Martínez-Beltrán
May 20, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·A NawatheK S Khan
Apr 18, 2014·Annals of the New York Academy of Sciences·Simone FerreroUmberto Leone Roberti Maggiore
May 9, 2014·Gynecologic Oncology·Chao GaoFengxia Xue
Aug 21, 2013·ISRN Obstetrics and Gynecology·Pedro Acién, Irene Velasco
Aug 1, 2010·Hormone Molecular Biology and Clinical Investigation·Jorge R Pasqualini, Gérard S Chetrite
Jul 24, 2012·Fertility and Sterility·Richard O Burney, Linda C Giudice
Feb 13, 2017·Fertility and Sterility·Soo Hyun AhnChandrakant Tayade
Jan 9, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yan-Yan FanLi-Na Wang
Apr 21, 2016·The Cochrane Database of Systematic Reviews·Devashana GuptaVicki Nisenblat
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Hanan Al KadriAli Hajeer
Jun 2, 2007·Obstetrics and Gynecology·Noha A MousaRobert F Casper
Feb 21, 2019·Reproductive Sciences·Osamu YoshinoShigeru Saito
May 16, 2008·Menopause : the Journal of the North American Menopause Society·Noha A MousaRobert F Casper
Apr 8, 2010·The Journal of Clinical Endocrinology and Metabolism·Johanie LépineChantal Guillemette

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