Aromatase inhibition reduces the dose of gonadotropin required for controlled ovarian hyperstimulation

Journal of the Society for Gynecologic Investigation
Mohamed F Mitwally, Robert F Casper

Abstract

To compare the use of the aromatase inhibitor, letrozole, in conjunction with follicle-stimulating hormone (FSH) injection, and FSH alone for controlled ovarian hyperstimulation (COH) in patients with polycystic ovarian syndrome (PCOS) or ovulatory infertility. This nonrandomized study included two study groups: 26 patients with PCOS and 63 with ovulatory infertility (unexplained infertility [41 patients], male factor infertility [17 patients], and endometriosis [5 patients]), who received letrozole in addition to FSH; and two control groups: 46 PCOS patients and 308 with ovulatory infertility (unexplained infertility [250 patients], male factor infertility [42 patients], and endometriosis [16 patients], who received FSH only. All patients had intrauterine insemination (IUI). Main outcome measures included dose of FSH used per cycle, number of preovulatory follicles greater than 16 mm in diameter, cancellation rate, and pregnancy rate. The FSH dose required for ovarian stimulation was significantly lower when letrozole was used in both study groups compared to the control groups without a significant difference in number of follicles greater than 16 mm. IUI cancellation rate was significantly lower with letrozole treatment in P...Continue Reading

Associated Clinical Trials

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Citations

May 28, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N H TurnerL Biganzoli
Jan 17, 2012·Human Reproduction·Paul B MillerBruce A Lessey
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Aug 1, 2006·Human Reproduction·Mohamed A BedaiwyRobert F Casper
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