Aromatase inhibitors and the risk of colorectal cancer in postmenopausal women with breast cancer

Annals of Oncology : Official Journal of the European Society for Medical Oncology
F Khosrow-KhavarL Azoulay

Abstract

A large trial of postmenopausal women with breast cancer reported an imbalance in colorectal cancer events with aromatase inhibitors (AIs), compared with tamoxifen in the adjuvant setting. This unexpected signal was observed within 3 years of randomization. To date, no observational studies have examined this important safety question in the natural setting of clinical practice. Thus, the objective of this study was to determine whether AIs, when compared with tamoxifen, are associated with increased risk of colorectal cancer in postmenopausal women with breast cancer. Using the UK Clinical Practice Research Datalink, we identified women, at least 55 years of age, with breast cancer newly treated with either AIs or tamoxifen between 1 January 1996 and 30 September 2015, with follow-up until 30 September 2016. High-dimensional propensity score-adjusted Cox proportional hazards models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) of incident colorectal cancer associated with AIs when compared with tamoxifen overall, by cumulative duration of use, and time since initiation. All exposures were lagged by 1 year for latency considerations. A total of 9701 and 8893 patients initiated AIs and tamoxifen a...Continue Reading

References

Jun 16, 1999·Breast Cancer Research and Treatment·P A NewcombE White
Jan 19, 2010·British Journal of Clinical Pharmacology·Emily HerrettAndrew J Hall
Nov 12, 2010·Journal of the National Cancer Institute·Jennifer H Lin, Edward Giovannucci
Mar 3, 2011·International Journal of Cancer. Journal International Du Cancer·Kueiyu Joshua LinEdward L Giovannucci
Jul 12, 2011·Journal of the National Cancer Institute·Eitan AmirAlberto Ocaña
Dec 15, 2012·Pharmacoepidemiology and Drug Safety·Rachael BoggonMike A Richards
Mar 9, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P Niravath
Aug 24, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Afsaneh BarziHeinz-Josef Lenz
Nov 5, 2014·Journal of Clinical Pharmacy and Therapeutics·E KellyA Vitry
Feb 24, 2015·Frontiers in Oncology·Francesco CaiazzaKieran Sheahan
Jun 4, 2015·Cancer·Sayeh LavasaniMichael S Simon
Jun 8, 2015·International Journal of Epidemiology·Emily HerrettLiam Smeeth
Jul 28, 2015·Lancet·UNKNOWN Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
Sep 1, 2015·World Journal of Biological Chemistry·Franco LumachiStefano Mm Basso
Oct 6, 2015·Pharmacoepidemiology and Drug Safety·Lucía Cea SorianoLuis A García Rodríguez

❮ Previous
Next ❯

Citations

Sep 27, 2019·Journal of Cellular and Molecular Medicine·Juan-Cheng YangWen-Lung Ma
Apr 28, 2020·American Journal of Epidemiology·Farzin Khosrow-KhavarLaurent Azoulay
Nov 15, 2021·American Journal of Obstetrics and Gynecology·Nan HuoMichelle M Mielke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.