Aromatase inhibitors in breast cancer: a review of cost considerations and cost effectiveness

PharmacoEconomics
Jonathan Karnon

Abstract

Aromatase inhibitors (AIs) have been evaluated clinically in a wide range of breast cancer treatment settings. Although these agents appear to have clinical superiority, they are more expensive than the therapies (primarily tamoxifen) they have been compared with, thus economic evaluation is required to consider their incremental value to the payer. This paper reviews published economic evaluations of AIs as first-line therapy for advanced cancer, and as adjuvant therapy for early breast cancer. The evaluations in the advanced setting demonstrate a range of different modelling techniques and consider the payer's perspective in three healthcare systems. There is broad similarity in the application of standard cohort Markov modelling techniques to evaluate AIs in the early breast cancer setting, covering four separate health system perspectives. AIs appear cost effective compared with current practice. An analysis in the advanced setting suggests that letrozole may be the more cost-effective AI. No direct comparisons of alternative AIs in the adjuvant setting are reported, although indirect comparisons may be feasible. Future evaluations of treatment strategies over the entire course of the disease may also be needed.

References

Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P DombernowskyP F Trunet
Apr 14, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B P WillW K Evans
May 18, 2000·Cancer Treatment Reviews·M StocklerR J Simes
Sep 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C C EarleP J Neumann
Nov 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J BonneterreM von Euler
Nov 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M NabholtzM von Euler
Jul 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A BuzdarC Brady
May 2, 2003·Expert Review of Anticancer Therapy·Yasuhiro TamakiShinzaburo Noguchi
Oct 29, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J KarnonA Glendenning
Mar 12, 2004·The New England Journal of Medicine·R Charles CoombesUNKNOWN Intergroup Exemestane Study
Jul 31, 2004·Cancer Control : Journal of the Moffitt Cancer Center·Michael Baum
Feb 9, 2006·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·M NuijtenD Parison

❮ Previous
Next ❯

Citations

May 19, 2006·PharmacoEconomics·Christopher Dunn, Susan J Keam
Sep 21, 2006·Journal of the National Cancer Institute·Catherine H Van Poznak, Daniel F Hayes
Feb 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicola Lucio LiberatoGiovanni Barosi
Oct 5, 2007·Breast Cancer Research and Treatment·Tallal YounisChris Skedgel
Jul 10, 2017·Breast Cancer Research and Treatment·Xavier Ghislain Léon Victor PouwelsManuela A Joore
Apr 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeanne S MandelblattPatricia A Ganz
Aug 31, 2016·Breast Cancer Research and Treatment·Virginie NerichBernhard Holzner
Feb 4, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Beatrice J EdwardsTheresa A Guise
Nov 11, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T YounisC Skedgel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.