Aromatase inhibitors in the treatment of bladder endometriosis

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Simone FerreroValentino Remorgida

Abstract

Aromatase inhibitors have recently been proposed for the treatment of endometriosis; however, no previous study examined the effects of these agents on pain and urinary symptoms of premenopausal women with bladder endometriosis. Two premenopausal patients with bladder endometriosis were treated with letrozole (2.5 mg/day), norethisterone acetate (2.5 mg/day), elemental calcium and vitamin D3 for 6 months. The double-drug regimen quickly improved pain and urinary symptoms in both patients. One patient had no significant adverse effect and continued the therapy for 14 months. The other patient developed myalgia and severe arthralgia; pain and urinary symptoms recurred few months after the interruption of the 6-month treatment and the patient underwent laparoscopic partial cystectomy. Aromatase inhibitors improve pain and urinary symptoms in patients with bladder endometriosis; however, severe side effects of treatment may occur. These agents should be administered only to patients who refuse surgery and fail to respond to other therapies.

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Citations

Jun 23, 2011·Reproductive Biology and Endocrinology : RB&E·Warren B Nothnick
Jun 23, 2011·Reproductive Biology and Endocrinology : RB&E·Simone FerreroValentino Remorgida
Jan 7, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Simone FerreroUmberto Leone Roberti Maggiore
Apr 18, 2014·Annals of the New York Academy of Sciences·Simone FerreroUmberto Leone Roberti Maggiore
Oct 11, 2014·The Journal of Obstetrics and Gynaecology Research·Sugandha AgarwalSukhbir Sony Singh
Sep 4, 2014·International Urogynecology Journal·Umberto Leone Roberti MaggioreStefano Salvatore
Sep 28, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Maria SzubertJacek Suzin
Jul 6, 2018·Expert Opinion on Pharmacotherapy·Simone FerreroFabio Barra
Feb 15, 2019·Expert Opinion on Biological Therapy·Fabio BarraSimone Ferrero

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