Aromatic acid metabolites of Escherichia coli K-12 can induce the marRAB operon.

Journal of Bacteriology
Lon M Chubiz, Christopher V Rao

Abstract

MarR is a key regulator of the marRAB operon involved in antibiotic resistance and solvent stress tolerance in Escherichia coli. We show that two metabolic intermediates, 2,3-dihydroxybenzoate and anthranilate, involved in enterobactin and tryptophan biosynthesis, respectively, can activate marRAB transcription. We also found that a third intermediate involved in ubiquinone biosynthesis, 4-hydroxybenzoate, activates marRAB transcription in the absence of TolC. Of the three, however, only 2,3-dihydroxybenzoate directly binds MarR and affects its activity.

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Citations

Mar 15, 2011·Journal of Bacteriology·Lon M Chubiz, Christopher V Rao
Aug 23, 2011·Journal of Bacteriology·Yusuke MinatoClaudia C Häse
Jul 2, 2014·PloS One·Marijke FrederixAindrila Mukhopadhyay
Sep 18, 2013·The Journal of Antimicrobial Chemotherapy·Cristian Ruiz, Stuart B Levy
Apr 14, 2016·Trends in Microbiology·Randi L Guest, Tracy L Raivio
Mar 13, 2018·Nucleic Acids Research·Tomohiro ShimadaAkira Ishihama
Apr 22, 2016·Molecular BioSystems·Kirti Jain, Supreet Saini
Nov 1, 2016·Applied and Environmental Microbiology·Kaitlin E CreamerJoan L Slonczewski
Sep 25, 2018·Expert Opinion on Therapeutic Targets·Petra Zimmermann, Nigel Curtis
Jun 9, 2019·Applied and Environmental Microbiology·Jeremy P MooreJoan L Slonczewski
Jun 5, 2021·Applied and Environmental Microbiology·Samantha H SchaffnerJoan L Slonczewski

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