Aromatic Amino Acids: A Complex Network Ripe for Future Exploration

Trends in Plant Science
Joseph H Lynch, Natalia Dudareva

Abstract

In plants, high carbon flux is committed to the biosynthesis of phenylalanine, tyrosine, and tryptophan, owing to their roles not only in the production of proteins, but also as precursors to thousands of primary and specialized metabolites. The core plastidial pathways that supply the majority of aromatic amino acids (AAAs) have previously been described in detail. More recently, the discovery of cytosolic enzymes contributing to overall AAA biosynthesis, as well as the identification of intracellular transporters and the continuing elucidation of transcriptional and post-transcriptional regulatory mechanisms, have revealed the complexity of this intercompartmental metabolic network. Here, we review the latest breakthroughs in AAA production and use the newest findings to highlight both longstanding and newly developed questions.

References

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Citations

Feb 6, 2021·Biochemical Society Transactions·Wanting Jiao
Aug 18, 2021·The Plant Journal : for Cell and Molecular Biology·Heejin YooNatalia Dudareva
Jan 7, 2022·World Journal of Microbiology & Biotechnology·Shuai LiuWei-Guo Zhang

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